两兄弟患家族性睾丸生殖细胞肿瘤。
Familial testicular germ cell tumors in two brothers.
作者信息
Hoshi Senji, Bilim Vladimir, Hoshi Kiyotsugu, Sasagawa Isoji, Otake Kotarou, Chiba Daigo, Suenaga Shinta, Konno Masahito, Katsumata Yuki, Morozumi Kento, Takemoto Jun, Numahata Kenji, Ito Keiichi
机构信息
Department of Urology Yamagata Tokushukai Hospital Yamagata Japan.
Department of Urology Kameda Daiichi Hospital Niigata Japan.
出版信息
IJU Case Rep. 2020 Apr 12;3(3):100-102. doi: 10.1002/iju5.12156. eCollection 2020 May.
INTRODUCTION
Two percent of testicular germ cell tumors occur in family clusters. Here, we report metachronous testicular germ cell tumors in two brothers.
CASE PRESENTATION
An elder brother was diagnosed at the age of 30 years old and the pathological diagnosis was mixed testicular germ cell tumor. A tumor in the younger brother was suspected during testicular self-examination. It was confirmed by ultrasound examination at the age of 30 years old, 3 years and 6 months after the diagnosis of the testicular tumor in elder brother. The pathological diagnosis was pure seminoma. Both brothers had stage 1 testicular germ cell tumors and no recurrence was observed during the follow-up period of 4 years and 4 months and 10 months, respectively.
CONCLUSION
Various histological types of tumor can occur in members of one family. Besides genetic predisposition, shared diet, environmental exposure and other factors can contribute to the familial testicular cancer. Testicular self-examination is recommended for family members of a person with testicular germ cell tumor.
引言
2%的睾丸生殖细胞肿瘤发生于家族聚集性病例中。在此，我们报告两兄弟先后发生的睾丸生殖细胞肿瘤。
病例介绍
哥哥30岁时被诊断出患有混合性睾丸生殖细胞肿瘤。弟弟在睾丸自检时怀疑患有肿瘤。在哥哥被诊断出睾丸肿瘤3年零6个月后的30岁时，经超声检查得以确诊。病理诊断为纯精原细胞瘤。两兄弟均为1期睾丸生殖细胞肿瘤，在分别随访4年零4个月和10个月期间均未观察到复发情况。
结论
一个家族的成员中可能出现各种组织学类型的肿瘤。除了遗传易感性外，共同的饮食、环境暴露及其他因素也可能导致家族性睾丸癌。建议睾丸生殖细胞肿瘤患者的家庭成员进行睾丸自检。
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