Motta Francesca, Carena Maria Cristina, Selmi Carlo, Vecellio Matteo
Division of Rheumatology and Clinical Immunology, Humanitas Research Hospital, IRCCS, Rozzano, Milan, Italy.
Humanitas Research Hospital, Rozzano, Milan, Italy.
J Transl Autoimmun. 2020 Mar 21;3:100050. doi: 10.1016/j.jtauto.2020.100050. eCollection 2020.
Epigenetic mechanisms such as DNA methylation, histone modifications and non-coding RNA, are considered the essential connection between a disorder's onset and the environment, on a permissive genetic background. Among autoimmune and inflammatory-mediated disorders, Ankylosing Spondylitis (AS), a chronic arthritis of the spine, is a very good example for the weight of epigenetics' contribution. MicroRNAs (miRNAs) are single-stranded nucleotides which regulate gene expression and are involved in pathological and physiological processes. In this manuscript we provide a clarification on the role of microRNAs in AS, with a focus on the mechanisms of pathogenesis. In specific, we have examined the contribution of miRNAs in the processes of inflammation, new bone formation and T-cell function, and the pathways (i.e. Wnt, BMP, TGFβ signalling etc.) they regulate. The utility of miRNAs in better understanding AS pathogenesis is undisputed and their utility as therapeutic opportunity is strongly increasing.
诸如DNA甲基化、组蛋白修饰和非编码RNA等表观遗传机制，在允许的遗传背景下，被认为是疾病发病与环境之间的重要联系。在自身免疫性和炎症介导的疾病中，强直性脊柱炎（AS），一种脊柱慢性关节炎，是表观遗传学贡献重要性的一个很好例子。微小RNA（miRNA）是调节基因表达并参与病理和生理过程的单链核苷酸。在本手稿中，我们阐明了微小RNA在AS中的作用，重点是发病机制。具体而言，我们研究了miRNA在炎症、新骨形成和T细胞功能过程中的作用，以及它们所调节的途径（即Wnt、BMP、TGFβ信号等）。miRNA在更好地理解AS发病机制方面的效用是无可争议的，并且它们作为治疗靶点的效用正在迅速增加。
