School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen, Guangdong 518060, China.
State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, 199 Ren'ai Road, Suzhou 215123, China.
J Mater Chem B. 2020 Aug 19;8(32):7042-7061. doi: 10.1039/d0tb00570c.
Stimuli-responsive polymers exhibit properties that make them ideal candidates for biosensing and molecular diagnostics. Through rational design of polymer composition combined with new polymer functionalization and synthetic strategies, polymers with myriad responsivities, e.g., responses to temperature, pH, biomolecules, CO2, light, and electricity can be achieved. When these polymers are specifically designed to respond to biomarkers, stimuli-responsive devices/probes, capable of recognizing and transducing analyte signals, can be used to diagnose and treat disease. In this review, we highlight recent state-of-the-art examples of stimuli-responsive polymer-based systems for biosensing and bioimaging.
刺激响应聚合物具有使其成为生物传感和分子诊断理想候选物的特性。通过合理设计聚合物组成，结合新的聚合物功能化和合成策略，可以实现具有多种响应性的聚合物，例如对温度、pH 值、生物分子、CO2、光和电的响应。当这些聚合物被专门设计为响应生物标志物时，能够识别和转换分析物信号的刺激响应器件/探针可用于诊断和治疗疾病。在这篇综述中，我们重点介绍了用于生物传感和生物成像的刺激响应聚合物基系统的最新最先进实例。
