Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
Department of Neurological Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan.
J Nucl Cardiol. 2022 Apr;29(2):569-577. doi: 10.1007/s12350-020-02300-3. Epub 2020 Aug 2.
This preliminary study was undertaken to evaluate relationship among the degree of internal carotid artery (ICA) stenosis, wall shear stress (WSS) by computational fluid dynamics (CFD) on magnetic resonance angiography (MRA) and F-FDG uptake of ICA on PET/CT.
A total of 40 carotid arteries in 20 patients with carotid atherosclerotic disease were examined with MRA and F-FDG PET/CT. Atherosclerotic risk factors were assessed in all patients. Degree of ICA stenosis was calculated according to NASCET method. CFD analysis was performed and maximum WSS (WSSmax) was measured. F-FDG uptake in ICA was quantified using maximum target-to-blood pool ratio (TBRmax).
Atherosclerotic risk factors did not affect imaging findings. There were significant correlations between WSSmax and degree of ICA stenosis (ρ = .81, P < .001), WSSmax and TBRmax (ρ = .64, P < .001), and TBRmax and degree of ICA stenosis (ρ = .50, P = .001).
These preliminary results indicate that there may be significant correlations among the degree of ICA stenosis, WSSmax and TBRmax in patients with carotid artery stenosis.
本初步研究旨在评估颈内动脉（ICA）狭窄程度、磁共振血管造影（MRA）上计算流体动力学（CFD）的壁切应力（WSS）和 ICA 的 F-FDG 摄取之间的关系。
共对 20 例颈动脉粥样硬化患者的 40 条颈动脉进行了 MRA 和 F-FDG PET/CT 检查。对所有患者进行了动脉粥样硬化危险因素评估。根据 NASCET 方法计算 ICA 狭窄程度。进行 CFD 分析并测量最大 WSS（WSSmax）。使用最大靶血池比（TBRmax）定量 ICA 中的 F-FDG 摄取。
动脉粥样硬化危险因素不影响影像学发现。ICA 狭窄程度与 WSSmax（ρ =.81，P <.001）、WSSmax 与 TBRmax（ρ =.64，P <.001）以及 TBRmax 与 ICA 狭窄程度（ρ =.50，P =.001）之间存在显著相关性。
这些初步结果表明，颈动脉狭窄患者的 ICA 狭窄程度、WSSmax 和 TBRmax 之间可能存在显著相关性。
