无痴呆症的老年人群听力损失与脑微观结构完整性。
Hearing loss and microstructural integrity of the brain in a dementia-free older population.
机构信息
Department of Otorhinolaryngology, Head and Neck Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands.
Cochlear Center for Hearing and Public Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
出版信息
Alzheimers Dement. 2020 Nov;16(11):1515-1523. doi: 10.1002/alz.12151. Epub 2020 Aug 2.
INTRODUCTION
As hearing loss has been identified as an important risk factor for dementia, we aimed to assess the association between hearing loss and microstructural integrity of the brain.
METHODS
A total of 1086 dementia-free participants (mean age = 75.2 [standard deviation: 4.9], 61.4% female) of the population-based Atherosclerosis Risk in Communities (ARIC) study underwent hearing assessment (2016-2017) and magnetic resonance imaging of the brain (2011-2013). Microstructural integrity was determined with diffusion tensor imaging. Multivariable linear regression was used to investigate associations between hearing loss and microstructural integrity of different brain regions and white matter (WM) tracts.
RESULTS
Hearing loss was associated with lower WM microstructural integrity in the temporal lobe, lower gray matter integrity of the hippocampus, and with lower WM microstructural integrity of the limbic tracts and the uncinate fasciculus.
CONCLUSION
Our results demonstrate that hearing loss is indepedently associated with lower microstructural integrity in brain regions that are important for different cognitive processes.
简介
听力损失已被确定为痴呆的一个重要危险因素，本研究旨在评估听力损失与大脑微观结构完整性之间的关系。
方法
本研究纳入了无痴呆症的 1086 名参与者（平均年龄为 75.2 [标准差：4.9]，61.4%为女性），他们均来自于基于人群的动脉粥样硬化风险研究（ARIC）。这些参与者在 2016-2017 年进行了听力评估，在 2011-2013 年进行了大脑磁共振成像（MRI）检查。使用弥散张量成像来确定微观结构的完整性。采用多变量线性回归来研究听力损失与不同脑区和白质（WM）束微观结构完整性之间的关系。
结果
听力损失与颞叶 WM 微观结构完整性降低、海马灰质完整性降低以及边缘束和钩束 WM 微观结构完整性降低有关。
结论
我们的研究结果表明，听力损失与不同认知过程中重要脑区的微观结构完整性降低有关。
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