Department of Neurology, Huashan Hospital, Institute of Science and Technology for Brain-Inspired Intelligence, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China; Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Department of Neurology, Huashan Hospital, Institute of Science and Technology for Brain-Inspired Intelligence, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
EBioMedicine. 2022 Dec;86:104336. doi: 10.1016/j.ebiom.2022.104336. Epub 2022 Nov 7.
Hearing impairment was recently identified as the most prominent risk factor for dementia. However, the mechanisms underlying the link between hearing impairment and dementia are still unclear.
We investigated the association of hearing performance with cognitive function, brain structure and cerebrospinal fluid (CSF) proteins in cross-sectional, longitudinal, mediation and genetic association analyses across the UK Biobank (N = 165,550), the Chinese Alzheimer's Biomarker and Lifestyle (CABLE, N = 863) study, and the Alzheimer's Disease Neuroimaging Initiative (ADNI, N = 1770) database.
Poor hearing performance was associated with worse cognitive function in the UK Biobank and in the CABLE study. Hearing impairment was significantly related to lower volume of temporal cortex, hippocampus, inferior parietal lobe, precuneus, etc., and to lower integrity of white matter (WM) tracts. Furthermore, a higher polygenic risk score (PRS) for hearing impairment was strongly associated with lower cognitive function, lower volume of gray matter, and lower integrity of WM tracts. Moreover, hearing impairment was correlated with a high level of CSF tau protein in the CABLE study and in the ADNI database. Finally, mediation analyses showed that brain atrophy and tau pathology partly mediated the association between hearing impairment and cognitive decline.
Hearing impairment is associated with cognitive decline, brain atrophy and tau pathology, and hearing impairment may reflect the risk for cognitive decline and dementia as it is related to bran atrophy and tau accumulation in brain. However, it is necessary to assess the mechanism in future animal studies.
A full list of funding bodies that supported this study can be found in the Acknowledgements section.
听力损伤最近被确定为痴呆症的最显著风险因素。然而，听力损伤与痴呆症之间的联系的机制仍不清楚。
我们通过英国生物银行（N=165550）、中国老年痴呆生物标志物和生活方式（CABLE）研究（N=863）和阿尔茨海默病神经影像学倡议（ADNI）数据库（N=1770）的横断面、纵向、中介和遗传关联分析，研究了听力表现与认知功能、大脑结构和脑脊液（CSF）蛋白之间的关联。
在英国生物银行和 CABLE 研究中，听力表现不佳与认知功能较差相关。听力损伤与颞叶皮质、海马体、下顶叶、楔前叶等体积减小，以及白质（WM）束完整性降低显著相关。此外，听力损伤的多基因风险评分（PRS）越高，认知功能越低，灰质体积越低，WM 束完整性越低。此外，在 CABLE 研究和 ADNI 数据库中，听力损伤与 CSF 中的 tau 蛋白水平升高相关。最后，中介分析表明，脑萎缩和 tau 病理学部分介导了听力损伤与认知能力下降之间的关联。
听力损伤与认知能力下降、脑萎缩和 tau 病理学有关，听力损伤可能反映了认知能力下降和痴呆的风险，因为它与大脑中的脑萎缩和 tau 积累有关。然而，有必要在未来的动物研究中评估其机制。
支持本研究的全部资助机构名单可在致谢部分找到。
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