Department of Neurosurgery and Pituitary Tumor Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Eur Rev Med Pharmacol Sci. 2020 Jul;24(14):7673-7680. doi: 10.26355/eurrev_202007_22268.
Our study aimed to investigate miR-193a-3p expression and its clinical significance in pituitary adenomas (PAs). Moreover, the correlation between miR-193a-3p expression and the invasiveness of PAs was explored.
In this study, the relative expression levels of miR-193a-3p were detected via quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). The correlations between miR-193a-3p and tumor size, clinical features, and prolactinomas postoperative prolactin (PRL) levels early remission were further analyzed.
Compared with non-invasive PAs, there was a lower miR-193a-3p expression in invasive PAs. MiR-193a-3p expression had reverse relevance to tumor size. A higher risk of postoperative residual and recurrence was found in patients with downregulated miR-193a-3p. Prolactinomas patients with postoperative PRL levels early remission were at lower risk to relapse and patients with high-expression miR-193a-3p had a higher early remission rate, suggesting that miR-193a-3p was a significant prognostic factor for prolactinomas.
MiR-193a-3p could have potential therapeutic value for invasive pituitary adenomas.
本研究旨在探讨 miR-193a-3p 在垂体腺瘤（PA）中的表达及其临床意义。此外，还探讨了 miR-193a-3p 表达与 PA 侵袭性之间的相关性。
本研究通过实时定量聚合酶链反应（qRT-PCR）检测 miR-193a-3p 的相对表达水平。进一步分析 miR-193a-3p 与肿瘤大小、临床特征以及泌乳素瘤术后催乳素（PRL）水平早期缓解之间的相关性。
与非侵袭性 PA 相比，侵袭性 PA 中 miR-193a-3p 的表达水平较低。miR-193a-3p 的表达与肿瘤大小呈负相关。miR-193a-3p 下调的患者术后残留和复发的风险更高。术后 PRL 水平早期缓解的泌乳素瘤患者复发风险较低，高表达 miR-193a-3p 的患者早期缓解率较高，提示 miR-193a-3p 是泌乳素瘤的一个重要预后因素。
miR-193a-3p 可能对侵袭性垂体腺瘤具有潜在的治疗价值。
