Copenhagen Centre for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark.
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
PLoS One. 2020 Aug 3;15(8):e0237117. doi: 10.1371/journal.pone.0237117. eCollection 2020.
To describe fatigue in relation to disease-specific and socioeconomic factors and to test possible correlations between fatigue and work impairment, quality of life, pain, sleep, depression, and physical functioning in people with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA).
A questionnaire-based cross-sectional survey collecting patient characteristics such as disease characteristics, socioeconomic factors and patient-reported outcomes (PROs) from patients with RA, PsA and axSpA in Denmark. PRO scales included the FACIT-Fatigue sub-scale, Work Productivity and Activity Impairment scale (WPAI), EuroQol (EQ-5D), Medical Outcomes Study Sleep Scale (MOS), Major Depression Inventory (MDI), and Health Assessment Questionnaire (HAQ). Respondents were recruited via routine visits to the outpatient rheumatology clinic; information on diagnosis, treatment and disease activity was collected from medical journals by trained nurses.
487 patients participated in the study. Fatigue was more present in women, experienced patients, and patients who changed medication in the past 12 months, who were unemployed, who had less education, and who had lower household income. There was no statistically significant difference between mean fatigue in the three diagnostic groups (p = 0.08). Fatigue correlated with all included PROs (Pearson correlation coefficients, p<0.0001). Stratifying for diagnosis and adjusting for socioeconomic factors did not change the conclusion.
In a stable, representative group of patients with RA, PsA and axSpA, we found significant correlations between fatigue and work impairment, quality of life, pain, sleep, depression and physical functioning. Fatigue cannot be perceived as a single problem, but rather as a symptom that affects broadly.
描述与疾病特异性和社会经济因素相关的疲劳，并检验疲劳与工作障碍、生活质量、疼痛、睡眠、抑郁和身体功能在类风湿关节炎（RA）、银屑病关节炎（PsA）和中轴型脊柱关节炎（axSpA）患者之间的可能相关性。
一项基于问卷的横断面调查，从丹麦的 RA、PsA 和 axSpA 患者中收集患者特征，如疾病特征、社会经济因素和患者报告的结局（PROs）。PRO 量表包括 FACIT-Fatigue 子量表、工作生产力和活动障碍量表（WPAI）、欧洲五维健康量表（EQ-5D）、医学结局研究睡眠量表（MOS）、抑郁自评量表（MDDI）和健康评估问卷（HAQ）。通过常规门诊就诊招募受访者；通过受过培训的护士从病历中收集有关诊断、治疗和疾病活动的信息。
共有 487 名患者参与了研究。女性、患病时间长的患者、过去 12 个月内改变药物治疗的患者、失业患者、受教育程度较低的患者以及家庭收入较低的患者中疲劳更为常见。在三个诊断组之间，疲劳的平均水平没有统计学上的显著差异（p=0.08）。疲劳与所有纳入的 PRO 均相关（Pearson 相关系数，p<0.0001）。按诊断分层并调整社会经济因素后，结论并未改变。
在一组稳定、具有代表性的 RA、PsA 和 axSpA 患者中，我们发现疲劳与工作障碍、生活质量、疼痛、睡眠、抑郁和身体功能之间存在显著相关性。疲劳不能被视为单一问题，而应被视为广泛影响的症状。
