Trimpert Jakob, Eichhorn Inga, Vladimirova Daria, Haake Alexander, Schink Anne-Kathrin, Klopfleisch Robert, Lübke-Becker Antina
Institut für Virologie, Freie Universität Berlin, Berlin, Germany.
Institut für Mikrobiologie und Tierseuchen, Freie Universität Berlin, Berlin, Germany.
Transbound Emerg Dis. 2021 Mar;68(2):931-940. doi: 10.1111/tbed.13761. Epub 2020 Aug 19.
This report describes an outbreak of Elizabethkingia miricola in northern leopard frogs (Lithobates pipiens) and three other species of frogs and toads held in captivity in Germany. The authors examine several treatment options and underline the difficulties in treating larger numbers of individuals with antimicrobials applied through bathing. Whole genome sequencing of three bacterial isolates emphasizes their relatedness to other frog isolates and leads us to conclude that E. miricola is an emerging and difficult to treat pathogen with a broad host range across anuran species. Moreover, ambiguities in identification of flavobacteria associated with disease in frogs reported in the literature make it seem possible that E. miricola has been overlooked as an anuran pathogen in the past.
本报告描述了德国圈养的北美豹蛙（Lithobates pipiens）以及其他三种蛙类和蟾蜍中发生的微小伊丽莎白菌（Elizabethkingia miricola）疫情。作者研究了几种治疗方案，并强调了通过药浴对大量个体使用抗菌药物进行治疗的困难。对三株细菌分离株进行的全基因组测序突显了它们与其他蛙类分离株的亲缘关系，使我们得出结论：微小伊丽莎白菌是一种新出现的、难以治疗的病原体，在无尾目物种中具有广泛的宿主范围。此外，文献中报道的与蛙类疾病相关的黄杆菌属细菌鉴定存在模糊性，这使得微小伊丽莎白菌在过去有可能被忽视，未被视为一种无尾目病原体。
