Institut des Sciences Moléculaires D'Orsay (ISMO), CNRS, Bâtiment 520, Université Paris-Saclay, F-91405, Orsay, France.
National Institute of Radiological Sciences (NIRS), National Institute for Quantum and Radiological Science and Technology (QST), 4-9-1, Anagawa, Inage, Chiba, 263-8555, Japan.
Free Radic Biol Med. 2020 Nov 1;159:103-106. doi: 10.1016/j.freeradbiomed.2020.06.019. Epub 2020 Jul 31.
Combining an external beam of ionizing particles with agents to augment the dose effects of cell damages for therapeutic purpose is an important goal of radiotherapy. This last decade intensive works have focused on metal compounds or metal nanoparticles as radiosensitizers to increase the oxidative damages under irradiation. In principle the nanoparticles can be coated with a functionalized shell, to achieve a specific targeting of the tissues, making such approach attractive. The functionalized coating is made of polymers. These molecules are able to scavenge the free radicals, thus, the coating can decrease the overall efficacy of the radiation. The purpose of the present model is to analyse the role of free hydroxyl radicals in the dual behaviour of the added agent. Consideration of the efficiency of the added agents versus the Linear Energy Transfer - LET - of the ionizing particles is made. It is shown that an efficient agent combined with a low-LET particle beams might become less efficient when high-LET particles like heavy-ions are used. These general considerations should be useful to optimize the design of the nanoparticles to be combined with the different kind of ionizing particles.
将外部离子束与增强细胞损伤剂量效应的试剂相结合，以达到治疗目的，这是放射治疗的一个重要目标。过去十年中，人们集中研究了金属化合物或金属纳米粒子作为放射增敏剂，以增加辐照下的氧化损伤。原则上，纳米粒子可以用功能化外壳包覆，以实现对组织的特异性靶向，从而使这种方法具有吸引力。功能化涂层由聚合物制成。这些分子能够清除自由基，因此，涂层会降低辐射的整体效果。本模型的目的是分析游离羟基自由基在添加试剂的双重行为中的作用。考虑了外加试剂的效率与电离粒子的线性能量转移（LET）之间的关系。结果表明，当使用像重离子这样的高 LET 粒子时，与低 LET 粒子束结合的高效试剂可能会变得效率降低。这些一般性考虑应该有助于优化与不同类型的电离粒子相结合的纳米粒子的设计。
