Yue Zongkai, Zhou Ruiren, Li Qingzhao, Ouyang Shaohu, Liu Lu, Zhou Qixing
Laboratory of Environmental Protection in Water Transport Engineering, Tianjin Research Institute for Water Transport Engineering, Ministry of Transport of the People's Republic of China, Tianjin 300456, China.
Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria/Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China.
Toxics. 2022 Nov 8;10(11):673. doi: 10.3390/toxics10110673.
The CdSe nanorod as a one-dimensional nanostructure has an excellent performance in many fields, such as healthcare, new energy, and environmental protection. Thus, it is crucial to investigate its potential adverse health effects prior to their wide exposure. The lung tissue would be the main target organ after CdSe nanorods enter living systems. Here, we showed that pulmonary instillation of CdSe nanorods could decrease the vitality of T-SOD and T-AOC in lung tissues of a rat, increase MDA and hydroxyproline levels and lipid peroxidation products, induce mitochondrial cristae breakage and vacuolization, cause inflammatory responses, and finally induce pulmonary fibrosis. The oral administration of modified procyanidinere could significantly increase the content of antioxidant enzymes, scavenge free radicals, reduce lipid peroxidation, and have protective effects on CdSe nanorods-induced pulmonary fibrosis. The benefit is not only in the early inflammatory stage but also in the later stages of the CdSe nanorods-induced pulmonary fibrosis.
作为一种一维纳米结构，CdSe纳米棒在医疗保健、新能源和环境保护等许多领域都具有优异的性能。因此，在其广泛暴露之前研究其潜在的健康不良影响至关重要。CdSe纳米棒进入生物系统后，肺组织将是主要的靶器官。在此，我们表明，经气管滴注CdSe纳米棒可降低大鼠肺组织中T-SOD和T-AOC的活力，增加MDA和羟脯氨酸水平以及脂质过氧化产物，诱导线粒体嵴断裂和空泡化，引起炎症反应，并最终诱发肺纤维化。口服改性原花青素可显著增加抗氧化酶的含量，清除自由基，减少脂质过氧化，对CdSe纳米棒诱导的肺纤维化具有保护作用。这种益处不仅体现在早期炎症阶段，也体现在CdSe纳米棒诱导的肺纤维化后期。
