Department of Oral Medicine and Diagnostic Sciences, AlFarabi Colleges of Dentistry and Nursing, Riyadh, Saudi Arabia.
Department of Oral Medicine, Oral Pathology and Oral Radiology, Faculty of Dentistry, Sana'a University, Yemen, Yemen.
J Oral Pathol Med. 2020 Nov;49(10):969-976. doi: 10.1111/jop.13093. Epub 2020 Aug 24.
Oral lichen planus (OLP) is a relatively common inflammatory disease, with unclear etiology. A number of studies have linked Epstein-Barr virus (EBV) with OLP. The present systematic review and meta-analysis aimed to evaluate the available evidence regarding the potential association between EBV and OLP.
Online databases (PubMed, Scopus, Web of Science, ProQuest, and Google Scholar) were searched from date of inception till May 2020. Studies were included if they met the following criteria: 1) observational studies that assessed the relationship between EBV and OLP, 2) the study comprised OLP patients and control subjects, 3) diagnosis of OLP was confirmed histopathologically, and 4) articles were in English. Studies without control groups, experimental studies, case reports, and reviews were excluded. The fixed-effects model was performed for meta-analyses using RevMan 5.3 software.
A total of 10 studies comprising 386 OLP cases and 304 controls were included. Of these, only 8 studies were eligible for the meta-analysis. The results of the quality assessment showed that only 2 studies were of high quality, while the remaining studies were of moderate quality. The results of the pooled eight studies revealed a significant positive association between EBV and OLP (OR = 4.41, 95% CI: [2.74, 7.11], P < .0001).
The results of the present systematic review suggest that EBV infection is statistically associated with increased risk of OLP. However, these results are preliminary, and high-quality, large-scale studies are warranted to further explore the potential role of EBV in the pathogenesis of OLP.
口腔扁平苔藓（OLP）是一种较为常见的炎症性疾病，其病因尚不明确。有多项研究将 Epstein-Barr 病毒（EBV）与 OLP 联系起来。本系统评价和荟萃分析旨在评估有关 EBV 与 OLP 之间潜在关联的现有证据。
从建库起至 2020 年 5 月，在线数据库（PubMed、Scopus、Web of Science、ProQuest 和 Google Scholar）进行检索。如果研究符合以下标准，则将其纳入：1）评估 EBV 与 OLP 之间关系的观察性研究，2）研究包含 OLP 患者和对照受试者，3）OLP 的诊断经组织病理学证实，以及 4）文章为英文。排除无对照组的研究、实验研究、病例报告和综述。使用 RevMan 5.3 软件进行荟萃分析采用固定效应模型。
共纳入 10 项研究，包含 386 例 OLP 病例和 304 例对照。其中，只有 8 项研究符合荟萃分析的纳入标准。质量评估结果显示，仅有 2 项研究质量较高，其余研究质量为中等。纳入的 8 项研究的汇总结果表明，EBV 与 OLP 之间存在显著的正相关（OR=4.41，95%CI：[2.74，7.11]，P<0.0001）。
本系统评价的结果表明，EBV 感染与 OLP 的发病风险增加具有统计学关联。然而，这些结果尚属初步，需要开展高质量、大规模的研究，以进一步探讨 EBV 在 OLP 发病机制中的潜在作用。
