Al-Amad Suhail H, AbuOdeh Raed O, Nair Vidhya Anish, Abdel-Rahman Wael M
Department of Oral and Craniofacial Health Sciences, College of Dental Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Department of Medical Laboratory Sciences, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates.
Sci Rep. 2025 Jul 24;15(1):26977. doi: 10.1038/s41598-025-12095-3.
To investigate the association between Epstein Barr virus (EBV) and Oral Lichen Planus (OLP) in both of its clinical phenotypes (erosive and non-erosive), 33 OLP cases divided into erosive and non-erosive phenotypes, and 26 non-OLP cases were evaluated for the presence of EBV using In Situ Hybridization. Immunohistochemistry was used to assess expressions of CD3, CD20, CD138 and p53 in both OLP clinical phenotypes. EBV was detected in 11 (33%) of the OLP cases and none of the non-OLP cases (p = 0.002). CD3 and CD20 were both over-expressed in all OLP cases, however CD138 was significantly over-expressed in the erosive OLP phenotype by comparison to the non-erosive one (p = 0.003), suggesting a possible role of plasma cell in erosive OLP. There was no association between EBV and CD-138, nor with erosive OLP. Interestingly however, EBV had an association with p53 expression among OLP cases (p = 0.038), inferring a role of EBV in possible neoplastic changes in OLP. There appears to be a potential role of EBV in causing at least some OLP cases, regardless of whether OLP is erosive or not. EBV might have an etiological role in causing some OLP cases. This could explain why some OLP cases are recalcitrant to corticosteroids treatment. Clinical trials are needed to establish whether EBV-infected OLP cases respond to antiviral therapy.
为了研究爱泼斯坦-巴尔病毒（EBV）与口腔扁平苔藓（OLP）两种临床表型（糜烂型和非糜烂型）之间的关联，我们对33例分为糜烂型和非糜烂型表型的OLP病例以及26例非OLP病例进行了原位杂交检测，以评估EBV的存在情况。采用免疫组织化学方法评估CD3、CD20、CD138和p53在OLP两种临床表型中的表达。在11例（33%）OLP病例中检测到EBV，而在非OLP病例中均未检测到（p = 0.002）。在所有OLP病例中CD3和CD20均过度表达，然而与非糜烂型OLP相比，CD138在糜烂型OLP表型中显著过度表达（p = 0.003），提示浆细胞在糜烂型OLP中可能发挥作用。EBV与CD - 138之间以及与糜烂型OLP均无关联。然而，有趣的是，在OLP病例中EBV与p53表达存在关联（p = 0.038），这意味着EBV在OLP可能的肿瘤性变化中发挥作用。无论OLP是否为糜烂型，EBV似乎在至少部分OLP病例的发生中具有潜在作用。EBV可能在某些OLP病例的病因学中发挥作用。这可以解释为什么一些OLP病例对皮质类固醇治疗无效。需要进行临床试验来确定EBV感染的OLP病例对抗病毒治疗是否有反应。
