Shaanxi Engineering and Technological Research Center for Conversation and Utilization of Regional Biological Resources, College of Life Sciences, Yan'an University, Yan'an, Shaanxi, China.
Yan'an University Affiliated Hospital, Yan'an, Shaanxi, China.
AIDS Res Hum Retroviruses. 2020 Nov;36(11):952-956. doi: 10.1089/AID.2020.0174. Epub 2020 Aug 27.
A wide variety of HIV-1 recombinants are constantly discovered in China. Comprehensively monitoring the genetic diversity of HIV-1 is very essential for understanding the molecular epidemiology and controlling the spread of the HIV-1 epidemic. In this study, we presented a novel HIV-1 unique CRF01_AE/C recombinant (19YA001) isolated from a female patient infected HIV-1 through heterosexual transmission in Yan'an city, Shaanxi province. The near full-length genome analyses showed 19YA001 was divided into two CRF01_AE and one C segments by two breakpoints observed in the / region. To date, this is the first report revealing the characteristic of HIV-1 subtype in Yan'an city. And this unique recombinant strain might imply that the genetic diversity of HIV-1 in Yan'an city is complex. However, the sample size is too small. Further larger studies of HIV-1 molecular epidemiology are urgently needed to provide a better understanding of HIV-1 diversity and transmission in this region.
在中国，不断发现各种各样的 HIV-1 重组体。全面监测 HIV-1 的遗传多样性对于了解分子流行病学和控制 HIV-1 流行的传播至关重要。在这项研究中，我们介绍了一种从陕西省延安市一名通过异性传播感染 HIV-1 的女性患者中分离出的新型 HIV-1 独特的 CRF01_AE/C 重组体（19YA001）。全长基因组分析表明，19YA001 通过两个断点分为两个 CRF01_AE 和一个 C 片段。迄今为止，这是首次揭示延安市 HIV-1 亚型特征的报告。这种独特的重组株可能表明延安市 HIV-1 的遗传多样性很复杂。但是，样本量太小。迫切需要进一步开展更大规模的 HIV-1 分子流行病学研究，以更好地了解该地区的 HIV-1 多样性和传播。
