Department of Nutrition and Health, Faculty of Medicine, Public Health, Nursing, Universitas Gadjah Mada, Yogyakarta55281, Indonesia.
Division of Nutrition and Dietetics, International Medical University, Kuala Lumpur57000, Malaysia.
Br J Nutr. 2021 Mar 28;125(6):611-617. doi: 10.1017/S0007114520003104. Epub 2020 Aug 4.
The present study aimed to investigate an interaction between energy intake, physical activity and UCP2 gene variation on weight gain and adiposity changes in Indonesian adults. This is a prospective cohort study conducted in 323 healthy adults living in the city of Yogyakarta, Indonesia. Energy intake, physical activity, body weight, BMI, percentage body fat and waist:hip ratio (WHR) were measured at baseline and after 2 years while UCP2 -866G/A gene variation was determined at baseline. We reported that after 2 years subjects had a significant increment in body weight, BMI, body fat and reduction in WHR (all P < 0·05). In all subjects, total energy intake was significantly correlated with changes in body weight (β = 0·128, P = 0·023) and body fat (β = 0·123, P = 0·030). Among subjects with the GG genotype, changes in energy intake were positively correlated with changes in body weight (β = 0·232, P = 0·016) and body fat (β = 0·201, P = 0·034). These correlations were insignificant among those with AA + GA genotypes (all P > 0·05). In summary, we show that UCP2 gene variation might influence the adiposity response towards changes in energy intake. Subjects with the GG genotype of UCP2 -866G/A gene were more responsive to energy intake, thus more prone to weight gain due to overeating.
本研究旨在探讨能量摄入、体力活动与 UCP2 基因变异在印度尼西亚成年人体重增加和体脂变化中的相互作用。这是一项在印度尼西亚日惹市的 323 名健康成年人中进行的前瞻性队列研究。在基线和 2 年后测量了能量摄入、体力活动、体重、BMI、体脂肪百分比和腰臀比（WHR），同时在基线时确定了 UCP2-866G/A 基因变异。我们报告称，2 年后，受试者的体重、BMI、体脂肪和 WHR 均显著增加（均 P < 0·05）。在所有受试者中，总能量摄入与体重变化（β=0·128，P=0·023）和体脂肪变化（β=0·123，P=0·030）显著相关。在 GG 基因型的受试者中，能量摄入的变化与体重变化（β=0·232，P=0·016）和体脂肪变化（β=0·201，P=0·034）呈正相关。在 AA+GA 基因型的受试者中，这些相关性均无统计学意义（均 P > 0·05）。综上所述，我们表明 UCP2 基因变异可能影响能量摄入变化引起的体脂反应。UCP2-866G/A 基因 GG 基因型的受试者对能量摄入的反应更为敏感，因此更容易因暴饮暴食而导致体重增加。
