Department of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Genes Dev. 2020 Aug 1;34(15-16):1005-1016. doi: 10.1101/gad.338962.120.
Over the past decade there has been increased awareness of the potential role of alternative splicing in the etiology of cancer. In particular, advances in RNA-Sequencing technology and analysis has led to a wave of discoveries in the last few years regarding the causes and functional relevance of alternative splicing in cancer. Here we discuss the current understanding of the connections between splicing and cancer, with a focus on the most recent findings. We also discuss remaining questions and challenges that must be addressed in order to use our knowledge of splicing to guide the diagnosis and treatment of cancer.
在过去的十年中，人们越来越意识到选择性剪接在癌症发病机制中的潜在作用。特别是，RNA 测序技术和分析方法的进步，导致了近年来在癌症中发现了大量关于选择性剪接的原因和功能相关性的发现。在这里，我们讨论了剪接与癌症之间的联系的现有认识，重点是最新的发现。我们还讨论了为了利用我们对剪接的了解来指导癌症的诊断和治疗，必须解决的遗留问题和挑战。
