Department of Surgery, VieCuri Medical Centre, Tegelseweg 210, 5912 BL, Venlo, The Netherlands.
Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
Sci Rep. 2020 Aug 3;10(1):13005. doi: 10.1038/s41598-020-69806-1.
Colorectal cancer (CRC) treatment is associated with a high morbidity which may result in a reduced health-related quality of life (HRQoL). The pre-operative measurement of handgrip strength (HGS) might be a tool to predict the patient's outcome after CRC surgery. The aim of this study was to evaluate the association of pre-operative HGS with the occurrence of postoperative complications and postoperative HRQoL. Stage I to III CRC patients ≥ 18 years were included at diagnosis. Demographic and clinical data as well as HGS were collected before start of treatment. HGS was classified as weak if it was below the gender-specific 25th percentile of our study population; otherwise HGS was classified as normal. The occurrence of postoperative complications within 30 days after surgery was collected from medical records. Cancer-specific HRQoL was measured 6 weeks after treatment using the EORTC QLQ-C30 and the EORTC QLQ-CR29 questionnaire. Of 295 patients who underwent surgical treatment for CRC, 67 (23%) patients had a weak HGS while 228 (77%) patients had normal HGS. 118 patients (40%) developed a postoperative complication. Complications occurred in 37% of patients with a weak HGS and in 41% of patients with a normal HGS (p = 0.47). After adjustment for age, sex, ASA, BMI and TNM, no significant associations between pre-operative HGS and the occurrence of postoperative complications and between HGS and HRQoL were found. We conclude that a single pre-operative HGS measurement was not associated with the occurrence of postoperative complications or post-treatment HRQoL in stage I-III CRC patients.
结直肠癌（CRC）的治疗相关发病率较高，可能导致健康相关生活质量（HRQoL）下降。术前握力（HGS）的测量可能是预测 CRC 手术后患者结局的一种工具。本研究旨在评估术前 HGS 与术后并发症和术后 HRQoL 的发生之间的关系。在诊断时纳入了年龄≥18 岁的 I-III 期 CRC 患者。在开始治疗前收集了人口统计学和临床数据以及 HGS。如果 HGS 低于我们研究人群的性别特异性第 25 百分位，则将其分类为弱；否则，HGS 被分类为正常。从病历中收集术后 30 天内发生的术后并发症。使用 EORTC QLQ-C30 和 EORTC QLQ-CR29 问卷在治疗后 6 周测量癌症特异性 HRQoL。在接受 CRC 手术治疗的 295 名患者中，有 67 名（23%）患者 HGS 较弱，228 名（77%）患者 HGS 正常。118 名（40%）患者发生术后并发症。HGS 较弱的患者中有 37%发生并发症，HGS 正常的患者中有 41%发生并发症（p=0.47）。在校正年龄、性别、ASA、BMI 和 TNM 后，术前 HGS 与术后并发症的发生以及 HGS 与 HRQoL 之间均无显著相关性。我们的结论是，在 I-III 期 CRC 患者中，单次术前 HGS 测量与术后并发症的发生或治疗后 HRQoL 无关。
