Department of Psychiatry, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Republic of Korea.
Department of Social Welfare, Seoul National University, Seoul, Republic of Korea.
Sci Rep. 2024 Apr 30;14(1):9876. doi: 10.1038/s41598-024-60710-6.
The purpose of this study is to investigate the association between handgrip strength (HGS) and health-related quality of life (HRQoL), demonstrating HGS as an effective indicator for evaluating HRQoL of patients with cancer. Analyzing 1657 Korean adult cancer patients (644 males, 1013 females) aged ≥ 20 years from the Korea National Health and Nutrition Examination Survey (2014-2019), HGS was standardized based on body mass index and categorized by sex. HRQoL was assessed using the Euro Quality of Life-5-Dimension 3-Level version (EQ-5D-3L) Index. Lower relative HGS was associated with decreased HRQoL in female patients, while no significant association was found in male patients. The lowest quartile of relative HGS exhibited a 2.5-fold decrease in HRQoL compared to the highest quartile (OR 2.50, 95% CI 1.59-3.95, p < 0.001). Both male and female patients with cancer were affected by age, subjective health perception, and stress recognition regarding HRQoL. This study suggests that HGS may be associated with the HRQoL of female patients with cancer, emphasizing that the HGS measurement can be effectively utilized as a pivotal tool for evaluating HRQoL in female patients with cancer.
本研究旨在探讨握力（HGS）与健康相关生活质量（HRQoL）之间的关联，证明 HGS 是评估癌症患者 HRQoL 的有效指标。对韩国全国健康和营养检查调查（2014-2019 年）中 1657 名≥20 岁的韩国成年癌症患者（644 名男性，1013 名女性）进行分析，根据体重指数对 HGS 进行标准化，并按性别进行分类。使用欧洲生活质量 5 维 3 级版（EQ-5D-3L）指数评估 HRQoL。女性患者相对较低的 HGS 与 HRQoL 下降相关，而男性患者则无显著相关性。与最高四分位相比，相对 HGS 的最低四分位 HRQoL 下降了 2.5 倍（OR 2.50，95%CI 1.59-3.95，p<0.001）。癌症男性和女性患者的 HRQoL 均受年龄、主观健康感知和压力识别的影响。本研究表明，HGS 可能与女性癌症患者的 HRQoL 相关，强调 HGS 测量可有效用作评估女性癌症患者 HRQoL 的关键工具。
