去酰胺化是否会影响对淀粉样蛋白聚集的抑制机制？

Does deamidation affect inhibitory mechanisms towards amyloid protein aggregation?

机构信息

Department of Chemistry, University of Warwick, Coventry, UK.

Department of Life Sciences, University of Warwick, Coventry, UK.

出版信息

Chem Commun (Camb). 2020 Aug 25;56(68):9787-9790. doi: 10.1039/d0cc03548c.

DOI:10.1039/d0cc03548c

PMID:32748913

Abstract

Deamidated amyloid proteins have been shown to accelerate fibril formation. Herein, the results show the inhibition performance and the interaction site between site-specific inhibitor and amyloid protein are significantly influenced by deamidation; while the inhibition mechanism of non-site specific inhibitor shows no significant disruption caused by amyloid protein deamidation.

摘要

已证实去酰胺的淀粉样蛋白能加速纤维形成。本文结果表明，去酰胺显著影响了靶向抑制剂与淀粉样蛋白之间的抑制性能和相互作用部位；而非靶向抑制剂的抑制机制并未因淀粉样蛋白的去酰胺而受到显著破坏。