T细胞发育与分化过程中的DNA甲基化
DNA Methylation in T-Cell Development and Differentiation.
作者信息
Correa Luis O, Jordan Martha S, Carty Shannon A
机构信息
Graduate Program in Immunology, University of Michigan, Ann Arbor, MI.
Department of Pathology and Laboratory Medicine; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
出版信息
Crit Rev Immunol. 2020;40(2):135-156. doi: 10.1615/CritRevImmunol.2020033728.
Abstract
T lymphocytes undergo carefully orchestrated programming during development in the thymus and subsequently during differentiation in the periphery. This intricate specification allows for cell-type and context-specific transcriptional programs that regulate immune responses to infection and malignancy. Epigenetic changes, including histone modifications and covalent modification of DNA itself through DNA methylation, are now recognized to play a critical role in these cell-fate decisions. DNA methylation is mediated primarily by the actions of the DNA methyltransferase (DNMT) and ten-eleven-translocation (TET) families of epigenetic enzymes. In this review, we discuss the role of DNA methylation and its enzymatic regulators in directing the development and differentiation of CD4+ and CD8+ T-cells.
摘要
T淋巴细胞在胸腺发育过程中以及随后在外周分化过程中经历精心编排的程序设定。这种复杂的特异性允许细胞类型和背景特异性的转录程序，从而调节对感染和恶性肿瘤的免疫反应。表观遗传变化，包括组蛋白修饰以及通过DNA甲基化对DNA本身的共价修饰，现在被认为在这些细胞命运决定中起关键作用。DNA甲基化主要由DNA甲基转移酶（DNMT）和表观遗传酶的十一-易位（TET）家族的作用介导。在本综述中，我们讨论DNA甲基化及其酶调节剂在指导CD4+和CD8+T细胞的发育和分化中的作用。
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本文引用的文献
1
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Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):16933-16942. doi: 10.1073/pnas.1903059116. Epub 2019 Aug 1.
2
Loss of TET2 and TET3 in regulatory T cells unleashes effector function.TET2 和 TET3 在调节性 T 细胞中的缺失会释放效应功能。
Nat Commun. 2019 May 1;10(1):2011. doi: 10.1038/s41467-019-09541-y.
3
Addition of Low-Dose Decitabine to Anti-PD-1 Antibody Camrelizumab in Relapsed/Refractory Classical Hodgkin Lymphoma.低剂量地西他滨联合抗 PD-1 抗体卡瑞利珠单抗治疗复发/难治性经典型霍奇金淋巴瘤。
J Clin Oncol. 2019 Jun 10;37(17):1479-1489. doi: 10.1200/JCO.18.02151. Epub 2019 Apr 30.
4
CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer.慢性病毒感染和癌症中的 CD8 T 细胞耗竭。
Annu Rev Immunol. 2019 Apr 26;37:457-495. doi: 10.1146/annurev-immunol-041015-055318. Epub 2019 Jan 24.
5
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Biochemistry. 2018 Oct 23;57(42):6061-6069. doi: 10.1021/acs.biochem.8b00683. Epub 2018 Oct 8.
6
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