Division of Gastroenterology, Department of Medicine, King Abdulaziz University, Building 10, Second Floor, P.O.Box 80215, Jeddah, 21589, Saudi Arabia.
Department of Pathology, King Abdulaziz University, Jeddah, Saudi Arabia.
Dig Dis Sci. 2021 Jul;66(7):2311-2316. doi: 10.1007/s10620-020-06503-z. Epub 2020 Aug 4.
While gastroesophageal reflux disease (GERD) is common in Middle Eastern countries, little data exists on the epidemiology of Barrett's esophagus (BE).
We aimed to determine the prevalence of BE among patients undergoing esophagogastroduodenoscopy (EGD) in a cohort of Saudi patients.
We retrospectively reviewed the endoscopy database at an academic tertiary care center. Consecutive adult patients who underwent an EGD for any indication between May 2014 and December 2018 were included. The prevalence of both endoscopically and histologically reported BE was determined. Multivariate regression analysis was used to identify factors associated with BE.
A total of 2805 patients were included. The mean age was 48 years (± 18.6) and 38.7% were male patients. BE was reported endoscopically in 18 (0.64%) and confirmed histologically in 9 patients (0.32%). Among patients with endoscopically reported BE, the mean age was 50.3 (± 16.1) years and 13 (72.2%) were male patients. Of patients with BE, short-segment BE was reported in 14 (77.8%) patients. Among the 9 patients with histologically confirmed BE; only one patient had dysplastic BE. On univariate analysis, BE was associated with male gender (p < 0.01), but not with age > 50, hiatal hernia, obesity or EGD performed for GERD related indications. On multivariate regression analysis, male gender was the only factor associated with BE (aOR 3.77, 95% CI 1.39-11.97, p = 0.01).
BE was endoscopically reported in 0.64% and histologically confirmed in 0.32% of this cohort of Saudi patients. Male gender was the only factor associated with BE.
胃食管反流病（GERD）在中东国家很常见，但关于巴雷特食管（BE）的流行病学数据很少。
我们旨在确定沙特患者队列中接受食管胃十二指肠镜检查（EGD）的患者中 BE 的患病率。
我们回顾性审查了一家学术性三级保健中心的内镜数据库。纳入 2014 年 5 月至 2018 年 12 月期间因任何原因接受 EGD 的连续成年患者。确定内镜和组织学报告的 BE 的患病率。使用多变量回归分析来确定与 BE 相关的因素。
共纳入 2805 例患者。平均年龄为 48 岁（±18.6），38.7%为男性患者。18 例（0.64%）内镜报告 BE，9 例（0.32%）组织学证实 BE。在有内镜报告 BE 的患者中，平均年龄为 50.3 岁（±16.1），13 例（72.2%）为男性患者。在有 BE 的患者中，有 14 例（77.8%）为短节段 BE。在 9 例组织学确诊的 BE 患者中，仅有 1 例为异型增生 BE。在单变量分析中，BE 与男性性别（p<0.01）相关，但与年龄>50 岁、食管裂孔疝、肥胖或因 GERD 相关指征进行 EGD 无关。在多变量回归分析中，男性是唯一与 BE 相关的因素（OR 3.77，95%CI 1.39-11.97，p=0.01）。
在本沙特患者队列中，内镜报告 BE 的发生率为 0.64%，组织学证实 BE 的发生率为 0.32%。男性是唯一与 BE 相关的因素。
