Gadour M O, Ayoola E A
Department of Gastroenterology, King Fahd Central Hospital, Gizan, Kingdom of Saudi Arabia.
Trop Gastroenterol. 1999 Jul-Sep;20(3):111-5.
BACKGROUND/AIMS: Gastrooesophageal reflux disease (GERD) and Barrett's oesophagus (BE) are presumed to be rare among non-western populations. This retrospective survery determined the prevalence of BE and its associated complications of dysplastic lesions (DL) and oesophageal adenocarcinoma (AD) among an Arabian population.
From 2572 patients who had endoscopy in King Fahd Central Hospital (KFCH) Gizan, Saudi Arabia, patients (n = 776) were selected for analysis if they had biopsies of the upper gastrointestinal (UGI) tract. The patients (159 of 776) with biopsy-proven oesophageal lesions were categorized and compared.
The relative frequencies of BE, DL and AD in 159 patients were 8(5%), 5(3%) and 16 (10%) respectively. These interpreted to prevalence rates of 0.31%, 1.9%, and 0.62% for the respective lesions. The comparison of the mean age +/- SD (in years) of the patients with BE (59.6 +/- 19.8), DL (66 +/- 16.7) and AD (70.6 +/- 12.2) showed to statistically significant difference. Major symptoms in the patients with BE were dyspepsia (4 cases), hematemesis (2 cases) and dysphagia (2 cases). This profile was not different from that observed in 79 patients with GERD.
The prevalence of 0.31% in our endoscopy population is at the lower range of the 0.3% to 10% reported in the western world. It is likely that the rate was underestimated by this retrospective survey, in which patients were selectively biopsied. Also, it is probable that the majority of individuals in our population with no or minimal symptoms of GERD do not present themselves or are not referred for evaluation. Despite this limitation, our study confirms the occurrence of BE and its complications among a Saudi population. The incidence of BE may increase with the current changes in the life-style and increase in the life-span of the Saudi Arabian population.
背景/目的：胃食管反流病（GERD）和巴雷特食管（BE）在非西方人群中被认为较为罕见。这项回顾性调查确定了阿拉伯人群中BE及其相关的发育异常病变（DL）和食管腺癌（AD）并发症的患病率。
在沙特阿拉伯吉赞法赫德国王中央医院（KFCH）接受内镜检查的2572例患者中，选取了776例进行上消化道（UGI）活检的患者进行分析。对159例经活检证实有食管病变的患者进行分类和比较。
159例患者中BE、DL和AD的相对频率分别为8例（5%）、5例（3%）和16例（10%）。这些分别对应病变的患病率为0.31%、1.9%和0.62%。BE患者（59.6±19.8岁）、DL患者（66±16.7岁）和AD患者（70.6±12.2岁）的平均年龄±标准差比较显示有统计学显著差异。BE患者的主要症状为消化不良（4例）、呕血（2例）和吞咽困难（2例）。这一情况与79例GERD患者中观察到的情况无异。
我们内镜检查人群中0.31%的患病率处于西方报道的0.3%至10%的较低范围。由于这项回顾性调查是对患者进行选择性活检，该患病率很可能被低估。此外，我们人群中大多数无GERD症状或症状轻微的个体可能未就医或未被转诊进行评估。尽管有此局限性，我们的研究证实了沙特人群中BE及其并发症的存在。随着沙特阿拉伯人群目前生活方式的改变和寿命的延长，BE的发病率可能会增加。
