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新型冠状病毒肺炎中的高凝状态:三例病例系列报告

Hypercoagulable State in COVID-19: A Case Series of Three Patients.

作者信息

Logan Gideon, Dub Larissa, Drone Emily, Ganti Latha, Webb Amanda L

机构信息

Emergency Medicine, University of Central Florida College of Medicine, Orlando, USA.

Emergency Medicine, University of Central Florida/Hospital Corporation of America/Graduate Medical Education Consortium and Osceola Regional Medical Center, Olrando, USA.

出版信息

Cureus. 2020 Jun 27;12(6):e8872. doi: 10.7759/cureus.8872.

DOI:10.7759/cureus.8872
PMID:32754409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7387071/
Abstract

The novel coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that originated in China in late 2019, has caused significant morbidity and mortality worldwide. Although fever, cough, and shortness of breath have been recognized as hallmark symptoms, other lesser known complications continue to be described. We report a series of three patients who presented to the emergency department, who tested positive for COVID-19, and were found to have or subsequently developed thromboembolic complications.

摘要

2019年新型冠状病毒病(COVID-19)大流行由2019年末起源于中国的严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起,已在全球范围内导致了显著的发病率和死亡率。尽管发热、咳嗽和呼吸急促已被公认为标志性症状,但其他鲜为人知的并发症仍在不断被描述。我们报告了一系列三名到急诊科就诊的患者,他们的COVID-19检测呈阳性,并被发现患有或随后出现了血栓栓塞并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f283/7387071/0edb72362603/cureus-0012-00000008872-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f283/7387071/611b12932bf1/cureus-0012-00000008872-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f283/7387071/68765f0adf9c/cureus-0012-00000008872-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f283/7387071/08c1783a2c99/cureus-0012-00000008872-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f283/7387071/0edb72362603/cureus-0012-00000008872-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f283/7387071/611b12932bf1/cureus-0012-00000008872-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f283/7387071/68765f0adf9c/cureus-0012-00000008872-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f283/7387071/08c1783a2c99/cureus-0012-00000008872-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f283/7387071/0edb72362603/cureus-0012-00000008872-i04.jpg

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本文引用的文献

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Will Complement Inhibition Be the New Target in Treating COVID-19-Related Systemic Thrombosis?补体抑制会成为治疗新冠病毒相关全身性血栓形成的新靶点吗?
Circulation. 2020 Jun 2;141(22):1739-1741. doi: 10.1161/CIRCULATIONAHA.120.047419. Epub 2020 Apr 9.
2
Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19.新型冠状病毒肺炎患者的凝血障碍与抗磷脂抗体
N Engl J Med. 2020 Apr 23;382(17):e38. doi: 10.1056/NEJMc2007575. Epub 2020 Apr 8.
3
Prominent changes in blood coagulation of patients with SARS-CoV-2 infection.SARS-CoV-2 感染患者凝血功能的显著变化。
Clin Chem Lab Med. 2020 Jun 25;58(7):1116-1120. doi: 10.1515/cclm-2020-0188.
4
Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia.异常的凝血参数与新型冠状病毒肺炎患者的预后不良有关。
J Thromb Haemost. 2020 Apr;18(4):844-847. doi: 10.1111/jth.14768. Epub 2020 Mar 13.
5
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.《武汉 2019 年新型冠状病毒感染的肺炎 138 例住院患者临床特征分析》
JAMA. 2020 Mar 17;323(11):1061-1069. doi: 10.1001/jama.2020.1585.