Department of Neurology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Brain Behav. 2020 Sep;10(9):e01709. doi: 10.1002/brb3.1709. Epub 2020 Aug 5.
Reduced thiamine (vitamin B ) had been reported to be associated with cognitive impairment caused by Alzheimer disease. Our study is to explore the association between thiamine and cognitive impairment after acute ischemic stroke.
One hundred and eighty two patients with acute cerebral infarction were recruited within the first 24 hr after admission. Thiamine and other vitamin Bs of peripheral blood samples were measured. Patients were divided into with poststroke cognitive impairment (PSCI) and non-PSCI according to the score of MMSE and the degree of education.
Reduced thiamine (<1.0 ng/ml) was independently associated with PSCI (OR: 2.033, 95% CI: 1.017-4.067, p = .045) after adjusting for potential confounding factors. Advanced age, lower education, diabetes mellitus, left hemisphere infarction, and higher National Institute of Health Stroke Scale (NIHSS) were also independent risk factors for PSCI.
Reduced thiamine is one of the predictors for early cognitive impairment in patients with acute cerebral infarction.
有报道称，体内硫胺素（维生素 B1）水平降低与阿尔茨海默病引起的认知障碍有关。本研究旨在探讨急性缺血性脑卒中后硫胺素与认知障碍的关系。
在入院后 24 小时内，共招募了 182 名急性脑梗死患者。检测外周血样本中的硫胺素和其他维生素 B。根据 MMSE 评分和受教育程度，将患者分为伴有和不伴有 poststroke 认知障碍（PSCI）的两组。
在校正了潜在混杂因素后，发现硫胺素降低（<1.0ng/ml）与 PSCI 独立相关（OR：2.033，95%CI：1.017-4.067，p=0.045）。高龄、受教育程度低、糖尿病、左侧大脑半球梗死和较高的国立卫生研究院卒中量表（NIHSS）评分也是 PSCI 的独立危险因素。
硫胺素降低是急性脑梗死患者早期认知障碍的预测因素之一。
