Gynecology Department, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Faculty of Dentistry, Biruni University, Istanbul, Turkey.
J Perinat Med. 2020 Jul 28;48(6):625-629. doi: 10.1515/jpm-2019-0469.
Objectives Preeclampsia is a hypertensive disorder associated with pregnancy and is the leading cause of both maternal and neonatal morbidity and mortality. Recent reports suggest that free radical-induced endothelial cell injury might be an etiologic factor in the pathogenesis of preeclampsia. The aim of this study was to determine the protective effects of vitamins C and E for the prevention of preeclampsia. Methods This clinical trial was conducted in the year 2018 in the clinical centers of Lorestan University of Medical Sciences. One hundred and sixty nulliparous women aged 18-38 years without any risk factors for preeclampsia were divided into two groups. The first group received a 400-IU/day dose of vitamin E orally and a 1000-mg/day dose of vitamin C with iron tablets during 20-24 weeks of pregnancy, while the control group received only iron tablets. Finally, the data were analyzed using descriptive statistics and frequency distribution tables. Results The incidence of preeclampsia in the control group was 17.5% and in the intervention group was 5%, which was significantly different. The mean systolic pressures before and after intervention were 99.43 ± 7.8 and 12.44 ± 19.1, respectively, in the control group, and 99.3 ± 8.3 and 106.12 ± 13.25, respectively, in the intervention group (P < 0.001). The mean diastolic pressures before and after intervention in the control group were 62.7 ± 13.6 and 62.7 ± 4.7 (P < 0.001), respectively. Conclusion The results of this study show that vitamins C and E have protective effects against preeclampsia by alleviating the overall blood pressure.
目的 子痫前期是一种与妊娠相关的高血压疾病，是母婴发病率和死亡率的主要原因。最近的报告表明，自由基诱导的内皮细胞损伤可能是子痫前期发病机制中的一个病因因素。本研究旨在确定维生素 C 和 E 的保护作用，以预防子痫前期。
方法 本临床试验于 2018 年在洛雷斯坦医科大学的临床中心进行。将 160 名无子痫前期危险因素的 18-38 岁初产妇分为两组。第一组在妊娠 20-24 周时口服每天 400IU 的维生素 E 和每天 1000mg 的维生素 C 加铁剂，而对照组仅服用铁剂。最后，采用描述性统计和频数分布表对数据进行分析。
结果 对照组子痫前期的发生率为 17.5%，干预组为 5%，差异有统计学意义。对照组干预前后的收缩压分别为 99.43±7.8 和 12.44±19.1，干预组分别为 99.3±8.3 和 106.12±13.25（P<0.001）。对照组干预前后的舒张压分别为 62.7±13.6 和 62.7±4.7（P<0.001）。
结论 本研究结果表明，维生素 C 和 E 通过缓解整体血压对子痫前期具有保护作用。
