National Institute of Nursing Research, National Institutes of Health , Bethesda, MD, USA.
Henry M. Jackson Foundation, Bethesda, MD, USA.
Brain Inj. 2020 Jul 28;34(9):1213-1221. doi: 10.1080/02699052.2020.1797171. Epub 2020 Aug 5.
To evaluate how blast exposure impacts peripheral biomarkers.
in military personnel enrolled in 10-day blast training.
On day 7, 21 military personnel experienced peak overpressure <2 pounds per square inch (psi); while 29 military personnel experienced peak overpressure ≥5 psi. Blood samples were collected each day to measure changes in amyloid beta (Aβ), neurofilament light chain (NFL), and tau concentrations.
Within 24 hours following exposure ≥5 psi, the ≥5 psi group had lower Aβ42 ( = .004) and NFL ( < .001) compared to the <2 psi group and lower Aβ42 (9.35%) and NFL (22.01%) compared to baseline. Twenty-four hours after ≥5 psi exposure, the ≥5 psi group had lower tau ( < .001) and NFL ( < .001) compared to the <2 psi group and baseline. Seventy-two hours after exposure ≥5 psi, tau increased in the ≥5 psi group compared to the <2 psi group ( = .02) and baseline. The tau:Aβ42 ratio 24 hours after blast ( = .012), and the Aβ40:Aβ42 ratio 48 hours after blast ( = .04) differed in the ≥5 psi group compared to the <2 psi group.
These findings provide an initial report of acute alterations in biomarker concentrations following blast exposure.
评估爆炸暴露对外周生物标志物的影响。
在参加为期 10 天爆炸训练的军事人员中。
在第 7 天，21 名军事人员经历了峰值超压<2 磅/平方英寸（psi）；而 29 名军事人员经历了峰值超压≥5 psi。每天采集血液样本以测量淀粉样蛋白 β（Aβ）、神经丝轻链（NFL）和 tau 浓度的变化。
在暴露于≥5 psi 后的 24 小时内，≥5 psi 组的 Aβ42（=0.004）和 NFL（<0.001）均低于<2 psi 组，与基线相比，Aβ42（9.35%）和 NFL（22.01%）均较低。在暴露于≥5 psi 后 24 小时，≥5 psi 组的 tau（<0.001）和 NFL（<0.001）均低于<2 psi 组和基线。在暴露于≥5 psi 后 72 小时，与<2 psi 组和基线相比，≥5 psi 组的 tau 增加。在爆炸后 24 小时的 tau:Aβ42 比值（=0.012）和爆炸后 48 小时的 Aβ40:Aβ42 比值（=0.04）在≥5 psi 组与<2 psi 组之间存在差异。
这些发现提供了爆炸暴露后生物标志物浓度急性变化的初步报告。
