Vorn Rany, Naunheim Rosanne, Lai Chen, Wagner Chelsea, Gill Jessica M
School of Nursing, Johns Hopkins University, Baltimore, MD, United States.
National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, United States.
Front Neurosci. 2022 Apr 29;16:853616. doi: 10.3389/fnins.2022.853616. eCollection 2022.
Blast exposures that occur during training are common in military personnel; however, the biomarkers that relate to these subtle injuries is not well understood. Therefore, the purpose of this study is to identify the acute biomarkers related to blast injury in a cohort of military personnel exposure to blast-related training. Thirty-four military personnel who participated in the training program were included in this study. Blood samples were collected before and after repetitive blast-related training on days 2 ( = 19) and days 7 ( = 15). Serum concentration (pg/mL) of tau, glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and phosphorylated tau181 (p-tau181) were measured using an ultrasensitive immunoassay platform. We observed that serum p-tau181 concentrations were elevated after exposed to repetitive blast on days 2 (z = -2.983, = 0.003) and days 7 (z = -2.158, = 0.031). Serum tau (z = -2.272, = 0.023) and NfL (z = -2.158, = 0.031) levels were significantly elevated after exposure to repetitive blasts on days 7. Our findings indicate that blast exposure affects serum biomarkers indicating axonal injury.
训练期间发生的爆炸暴露在军事人员中很常见；然而，与这些轻微损伤相关的生物标志物尚未得到充分了解。因此，本研究的目的是在一组接受与爆炸相关训练的军事人员中确定与爆炸伤相关的急性生物标志物。本研究纳入了34名参加训练计划的军事人员。在第2天（n = 19）和第7天（n = 15）进行重复性爆炸相关训练前后采集血样。使用超灵敏免疫分析平台测量tau、胶质纤维酸性蛋白（GFAP）、神经丝轻链（NfL）和磷酸化tau181（p-tau181）的血清浓度（pg/mL）。我们观察到，在第2天（z = -2.983，P = 0.003）和第7天（z = -2.158，P = 0.031）暴露于重复性爆炸后，血清p-tau181浓度升高。在第7天暴露于重复性爆炸后，血清tau（z = -2.272，P = 0.023）和NfL（z = -2.158，P = 0.031）水平显著升高。我们的研究结果表明爆炸暴露会影响指示轴突损伤的血清生物标志物。
