压力与 IL-6 之间的联系正日益受到关注。
The Link between Stress and IL-6 Is Heating Up.
机构信息
Joslin Diabetes Center, Section on Integrative Physiology and Metabolism, Harvard Medical School, Boston, MA, USA.
Joslin Diabetes Center, Section on Integrative Physiology and Metabolism, Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.
出版信息
Cell Metab. 2020 Aug 4;32(2):152-153. doi: 10.1016/j.cmet.2020.07.011.
Abstract
Psychological stress has long been known to reduce adaptability to inflammatory challenges, although the precise mechanism has remained elusive. In a recent issue of Cell, Qing et al. (2020) demonstrate that psychological stress induces secretion of IL-6 from brown adipose tissue, which promotes hepatic gluconeogenesis, and reduces host fitness to inflammatory insults.
摘要
心理压力长期以来一直被认为会降低对炎症挑战的适应能力，尽管确切的机制仍未被揭示。在最近一期的《细胞》杂志上，Qing 等人（2020 年）表明，心理压力会导致棕色脂肪组织分泌白细胞介素 6（IL-6），从而促进肝脏的糖异生，降低宿主对炎症的适应能力。
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