克服神经退行性疾病和脑肿瘤的血脑屏障。
Overcoming the blood-brain barrier in neurodegenerative disorders and brain tumours.
机构信息
Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
IET Nanobiotechnol. 2020 Aug;14(6):441-448. doi: 10.1049/iet-nbt.2019.0351.
Abstract
Drug delivery is one of the major challenges in the treatment of central nervous system disorders. The brain needs to be protected from harmful agents, which are done by the capillary network, the so-called blood-brain barrier (BBB). This protective guard also prevents the delivery of therapeutic agents to the brain and limits the effectiveness of treatment. For this reason, various strategies have been explored by scientists for overcoming the BBB from disruption of the BBB to targeted delivery of nanoparticles (NPs) and cells and immunotherapy. In this review, different promising brain drug delivery strategies including disruption of tight junctions in the BBB, enhanced transcellular transport by peptide-based delivery, local delivery strategies, NP delivery, and cell-based delivery have been fully discussed.
摘要
药物递送是治疗中枢神经系统疾病的主要挑战之一。大脑需要受到毛细血管网络（即血脑屏障，BBB）的保护，防止有害物质进入。这种保护机制也阻止了治疗药物递送到大脑，限制了治疗的效果。出于这个原因，科学家们探索了各种策略来克服血脑屏障，包括破坏血脑屏障、通过基于肽的递送来靶向递送纳米颗粒（NPs）和细胞以及免疫疗法。在这篇综述中，全面讨论了不同有前途的脑内药物递送策略，包括破坏 BBB 中的紧密连接、通过基于肽的递送来增强细胞间转运、局部递药策略、NPs 递药和细胞递药。
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2
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3
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