Aghamiri Shahin, Jafarpour Ali, Malekshahi Ziba Veisi, Mahmoudi Gomari Mohammad, Negahdari Babak
Student Research Committee, Department of Medical Biotechnology, School of Advanced Technology in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Virology Division, Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
J Cell Physiol. 2019 Sep;234(9):14818-14827. doi: 10.1002/jcp.28281. Epub 2019 Mar 28.
Colorectal cancer (CRC) is known as one of the most important causes of death and mortality worldwide. Although several efforts have been made for finding new therapies, no achievements have been made in this area. Multidrug resistance (MDR) mechanisms are one of the key factors that could lead to the failure of chemotherapy. Moreover, it has been shown that various chemotherapy drugs are associated with several side effects. Hence, it seems that finding new drugs or new therapeutic platforms is required. Among different therapeutic approaches, utilization of nanoparticles (NPs) for targeting a variety of molecules such as siRNAs are associated with good results for the treatment of CRC. Targeting siRNA-mediated NPs could turn off the effects of oncogenes and MDR-related genes. In the current study, we summarized various siRNAs targeted by NPs which could be used for the treatment of CRC. Moreover, we highlighted other routes such as liposome for targeting siRNAs in CRC therapy.
结直肠癌（CRC）是全球最重要的死亡原因之一。尽管已经做出了多项努力来寻找新的治疗方法，但在这一领域尚未取得任何成果。多药耐药（MDR）机制是导致化疗失败的关键因素之一。此外，已经表明各种化疗药物都伴有多种副作用。因此，似乎需要寻找新的药物或新的治疗平台。在不同的治疗方法中，利用纳米颗粒（NPs）靶向多种分子（如siRNAs）在CRC治疗中取得了良好效果。靶向siRNA介导的NPs可以消除癌基因和MDR相关基因的作用。在本研究中，我们总结了NPs靶向的各种可用于CRC治疗的siRNAs。此外，我们还强调了其他途径，如脂质体，用于在CRC治疗中靶向siRNAs。
