新生儿基孔肯雅热的长期神经发育结局：一系列病例随访至 1 年。
Long-Term Neurodevelopmental Outcomes of Neonatal Chikungunya: Follow-Up of a Series of Cases Till 1 Year.
机构信息
Department of Neonatology, ABVIMS and Dr RML Hospital, New Delhi 110001, India.
出版信息
J Trop Pediatr. 2021 Jul 2;67(3). doi: 10.1093/tropej/fmaa053.
OBJECTIVES
Short- or long-term neurodevelopmental outcomes of Neonatal Chikungunya infection haven't been well described. In this study, we describe neurodevelopmental outcomes of a series of 13 infants.
METHODS
Study was conducted over a period of 1 year in high-risk follow-up clinic. Follow-up visits were conducted at 3, 6, 9, 12 ± 3 months.
PRIMARY OUTCOME
Development Quotient by Developmental Assessment Scales for Indian Infants. Secondary outcome: growth/anthropometric assessment, neuromotor/neurosensory and re-hospitalization rate.
RESULTS
DASII was <85 in three infants. Two other had expressive speech delay. Two, three and four babies had head circumference, length and weight below third centile, respectively. Two infants had persistent hypertonia and one had hypotonia. Two infants developed strabismus. Two infants had seizures persisting at 12 months requiring re-hospitalization.
CONCLUSION
Neonatal Chikungunya infection portends a poor neurodevelopmental outcome at 1 year of age. Careful neurodevelopmental follow-up is required for identification and management of sequelae.
目的
新生儿基孔肯雅热感染的短期或长期神经发育结局尚未得到很好的描述。在这项研究中，我们描述了一系列 13 名婴儿的神经发育结局。
方法
该研究在高危随访诊所进行了 1 年。随访在 3、6、9 和 12 ± 3 个月时进行。
主要结局
印度婴儿发育评估量表的发育商数。次要结局：生长/人体测量评估、神经运动/神经感觉和再住院率。
结果
三名婴儿的 DASII<85。另外两名婴儿有表达性语言延迟。两名、三名和四名婴儿的头围、长度和体重分别低于第三百分位。两名婴儿持续性高肌张力，一名婴儿低肌张力。两名婴儿出现斜视。两名婴儿在 12 个月时癫痫持续发作，需要再次住院治疗。
结论
新生儿基孔肯雅热感染预示着 1 岁时神经发育结局不佳。需要进行仔细的神经发育随访，以发现和管理后遗症。
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