Radzun H J, Kreipe H, Zavazava N, Hansmann M L, Parwaresch M R
Institute of Pathology, University of Kiel, Federal Republic of Germany.
J Leukoc Biol. 1988 Jan;43(1):41-50. doi: 10.1002/jlb.43.1.41.
Four monoclonal antibodies against the human monocyte/macrophage system, termed Ki-M1, Ki-M6, Ki-M7, and Ki-M8, are described with regard to their immunohistochemical tissue distribution pattern and their subcellular reactive sites. The differences found applying these analyses are also reflected by the various molecular weights of the recognized antigens. Based on these data it is proposed that the monocyte/macrophage system can be divided into the phagocytosing compartment on one hand and the immune accessory compartment on the other hand; the latter constitutes the interdigitating reticulum cells, the indeterminate dendritic cells, and the Langerhans cells, as well as the follicular dendritic cells (dendritic reticulum cells) as the accessory cells for T- and B-cell immune response, respectively.
描述了四种针对人单核细胞/巨噬细胞系统的单克隆抗体，分别称为Ki-M1、Ki-M6、Ki-M7和Ki-M8，涉及它们的免疫组织化学组织分布模式及其亚细胞反应位点。通过这些分析发现的差异也反映在被识别抗原的不同分子量上。基于这些数据，有人提出单核细胞/巨噬细胞系统一方面可分为吞噬区室，另一方面可分为免疫辅助区室；后者分别构成指状网状细胞、不定型树突状细胞和朗格汉斯细胞，以及作为T细胞和B细胞免疫反应辅助细胞的滤泡树突状细胞（树突状网状细胞）。
