化妆品遮瑕改善患有系统性红斑狼疮和永久性皮肤损伤的女性的健康相关生活质量：一项对照干预研究。

Cosmetic camouflage improves health-related quality of life in women with systemic lupus erythematosus and permanent skin damage: A controlled intervention study.

机构信息

School of Medicine, Universidade Federal of Minas Gerais, Universidade Federal of Minas Gerais-UFMG, Belo Horizonte, Brazil.

Department of Locomotor Apparatus, School of Medicine, Universidade Federal of Minas Gerais-UFMG, Belo Horizonte, Brazil.

出版信息

Lupus. 2020 Oct;29(11):1438-1448. doi: 10.1177/0961203320947802. Epub 2020 Aug 5.

DOI:10.1177/0961203320947802

PMID:32757736

Abstract

OBJECTIVE

To investigate the effect of cosmetic camouflage in health-related quality of life (HRQoL) in women with systemic lupus erythematosus (SLE) and permanent facial skin damage.

METHODS

This is a randomized controlled clinical trial (Universal Trial Number: U1111-1210-2554e) with SLE women from outpatients using ACR/1997 and/or SLICC/2012 criteria, aged over 18 years old, with modified SLEDAI 2k < 4 and permanent facial skin damage, recruited in two tertiary centers to use cosmetic camouflage (n = 36) or no intervention (n = 20). Endpoints were score variations in SLE Quality of Life (SLEQoL) (total and each domain), Dermatology Life Quality Index (DLQI), Rosenberg self-esteem scale and Hospital Anxiety and Depression Scale (HADS), after daily use of cosmetic camouflage for 12 +/-2 weeks (Phase I), "as needed" use of cosmetic camouflage for another 12 +/-2 weeks (Phase II), and during total follow up (24 +/-2 weeks). Univariate and multivariate linear regressions were conducted by protocol analysis.

RESULTS

Both groups were similar at baseline regarding age, disease duration, socio-demographic, clinical, laboratory and treatment characteristics. The comparison of score variations between intervention and control groups showed an independent HRQoL improvement in total SLEQoL score after using cosmetic camouflage in Phase I [β -27.56 (CI 95% -47.86 to -7.27) p = 0.009] and total follow up [β -28.04 (CI 95% -48.65 to -7.44) p = 0.09], specifically in mood, self-image and physical functioning domains. Also, there was an improvement in DLQI scores during Phase I [β -7.65 (CI 95% -12.31 to -3.00) p = 0.002] and total follow up [β -8.97(CI95% -12.99 to -4.94) p < 0.001). Scores for depression [β -1.92 (CI 95% -3.67 to -0.16) p = 0.033], anxiety [β -2.87 (CI 95% -5.67 to -0.07] p = 0.045] and self-esteem [β 2.79 (CI 95% 0.13 to 5.46) p = 0.041] improved considering the total follow up. No significant changes occurred in the control group scores.

CONCLUSION

The use of cosmetic camouflage improved the HRQoL in female SLE patients with permanent facial skin damage.

摘要

目的

探讨化妆品遮瑕对患有系统性红斑狼疮（SLE）且面部皮肤永久性损伤的女性健康相关生活质量（HRQoL）的影响。

方法

这是一项随机对照临床试验（通用试验编号：U1111-1210-2554e），纳入来自两个三级中心的门诊符合 ACR/1997 标准和/或 SLICC/2012 标准的 SLE 女性患者，年龄在 18 岁以上，SLEDAI 2k<4，面部皮肤永久性损伤，使用化妆品遮瑕（n=36）或不进行干预（n=20）。终点是在使用化妆品遮瑕 12 ± 2 周（第 I 阶段）后，使用化妆品遮瑕 12 ± 2 周（第 II 阶段），以及总随访（24 ± 2 周）后，SLE 生活质量（SLEQoL）（总分和各领域）、皮肤病生活质量指数（DLQI）、罗森伯格自尊量表和医院焦虑抑郁量表（HADS）评分的变化。根据方案进行单变量和多变量线性回归分析。

结果

两组在年龄、疾病持续时间、社会人口统计学、临床、实验室和治疗特征方面在基线时相似。干预组和对照组评分变化的比较显示，在第 I 阶段使用化妆品遮瑕后，SLEQoL 总分[β -27.56（95%CI-47.86 至-7.27），p=0.009]和总随访[β -28.04（95%CI-48.65 至-7.44），p=0.09]均有独立的 HRQoL 改善，特别是在情绪、自我形象和身体功能领域。此外，在第 I 阶段[β -7.65（95%CI-12.31 至-3.00），p=0.002]和总随访[β -8.97（95%CI-12.99 至-4.94），p<0.001]时，DLQI 评分也有所改善。抑郁评分[β -1.92（95%CI-3.67 至-0.16），p=0.033]、焦虑评分[β -2.87（95%CI-5.67 至-0.07），p=0.045]和自尊评分[β 2.79（95%CI 0.13 至 5.46），p=0.041]在总随访时也有所改善。对照组评分无显著变化。