Chen Hui-Juan, Wang Hong, Qiu Li-Juan, Ling Hua-Yun, Wu Ling-Ling, Wang Ting-Rui, Zhou Ying, Xue Yu, Ye Dong-Qing, Wang Bin
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, People's Republic of China.
The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei, People's Republic of China.
Patient Prefer Adherence. 2022 May 25;16:1351-1358. doi: 10.2147/PPA.S366083. eCollection 2022.
This study aimed to examine the relationship between anxiety, depression, sleep quality and health-related quality of life among systemic lupus erythematosus (SLE) patients in China.
After ethical approval and obtaining participants' informed consent, a cross-sectional study was conducted in The First Affiliated Hospital of Anhui Medical University between October 1, 2021 and January 30, 2022. The data comprised demographic information, number of SLE symptoms, Hospital Anxiety and Depression Scale (HADS), Pittsburgh Sleep Quality Index (PSQI) and Systemic Lupus Erythematosus-Specific Quality of Life Questionnaire (SLEQoL). We performed descriptive statistics, Spearman or Pearson correlations, and multiple linear regression. And Path analysis was performed to examine direct and indirect associations between these variables and health-related quality of life.
A total of 580 patients were recruited and 513 met our target criteria. Our final model fitted the data well: goodness-of-fit index (GFI) =0.996; adjusted goodness-of-fit index (AGFI) =0.974; comparative fit index (CFI) =0.998; root mean square error of approximation (RMSEA) =0.043. This model explained 57.3% of the variance on health-related quality of life (HRQoL) in patients with SLE and all the hypothesized paths reached significance (<0.05). Anxiety, depression, sleep quality, income/family, and number of SLE symptoms were related to health-related quality of life, and anxiety had the most influence on HRQoL (β=0.561).
The study model helps to explain the relation among anxiety, depression, sleep quality and health-related quality of life in patients with SLE. It also suggests that health care professionals should be aware of factors such as anxiety, sleep quality, number of SLE symptoms, and depression in their care for HRQoL of SLE patients.
本研究旨在探讨中国系统性红斑狼疮（SLE）患者的焦虑、抑郁、睡眠质量与健康相关生活质量之间的关系。
在获得伦理批准并取得参与者的知情同意后，于2021年10月1日至2022年1月30日在安徽医科大学第一附属医院进行了一项横断面研究。数据包括人口统计学信息、SLE症状数量、医院焦虑抑郁量表（HADS）、匹兹堡睡眠质量指数（PSQI）和系统性红斑狼疮特异性生活质量问卷（SLEQoL）。我们进行了描述性统计、Spearman或Pearson相关性分析以及多元线性回归。并进行了路径分析，以检验这些变量与健康相关生活质量之间的直接和间接关联。
共招募了580名患者，其中513名符合我们的目标标准。我们的最终模型与数据拟合良好：拟合优度指数（GFI）=0.996；调整后拟合优度指数（AGFI）=0.974；比较拟合指数（CFI）=0.998；近似均方根误差（RMSEA）=0.043。该模型解释了SLE患者健康相关生活质量（HRQoL）方差的57.3%，所有假设路径均具有统计学意义（<0.05）。焦虑、抑郁、睡眠质量、收入/家庭以及SLE症状数量与健康相关生活质量相关，其中焦虑对HRQoL的影响最大（β=0.561）。
该研究模型有助于解释SLE患者焦虑、抑郁、睡眠质量与健康相关生活质量之间的关系。这也表明医疗保健专业人员在照顾SLE患者的HRQoL时应注意焦虑、睡眠质量、SLE症状数量和抑郁等因素。
