Morgan T R, Laudone V P, Heston W D, Zeitz L, Fair W R
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
J Urol. 1988 Jan;139(1):186-9. doi: 10.1016/s0022-5347(17)42350-0.
Fricke chemical dosimetry is used as an indirect measure of the free radical production of ionizing irradiation. We adapted the Fricke ferrous sulfate radiation dosimeter to examine the chemical effects of high energy shock waves. Significant free radical production was documented. The reaction was dose dependent, predictably increased by acoustic impedance, but curvilinear. A thousand shocks at 18 kilovolts induced the same free radical oxidation as 1100 rad cobalt-60 gamma ionizing irradiation, increasing to 2900 rad in the presence of an air-fluid zone of acoustic impedance. The biological effect of these free radicals was compared to that of cobalt-60 ionizing irradiation by measuring the affect on Chinese hamster cells by clonogenic assay. While cobalt-60 irradiation produced a marked decrease in clonogenic survivors, little effect was noted with high energy shock waves. This suggested that the chemical effects produced by shock waves were either absent or attenuated in the cells, or were inherently less toxic than those of ionizing irradiation.
弗里克化学剂量测定法被用作电离辐射自由基产生的间接测量方法。我们对弗里克硫酸亚铁辐射剂量计进行了改进，以研究高能冲击波的化学效应。记录到了显著的自由基产生。该反应呈剂量依赖性，可预见地会因声阻抗而增加，但呈曲线关系。18千伏下的一千次冲击所引发的自由基氧化作用与1100拉德的钴-60伽马电离辐射相同，在存在声阻抗的气液区域时增加到2900拉德。通过克隆形成试验测量对中国仓鼠细胞的影响，将这些自由基的生物学效应与钴-60电离辐射的生物学效应进行了比较。虽然钴-60辐射使克隆形成存活者显著减少，但高能冲击波的影响很小。这表明冲击波产生的化学效应在细胞中要么不存在，要么被减弱，或者其固有毒性低于电离辐射的毒性。
