Serel Tekin Ahmet, Ozguner Fehmi, Soyupek Sedat
Department of Urology, School of Medicine, Süleyman Demirel University, Isparta, Turkey.
Urol Res. 2004 Feb;32(1):69-71. doi: 10.1007/s00240-003-0397-z. Epub 2004 Jan 15.
Our aim was to evaluate the effects of the potent endogenous free radical scavenger melatonin on extracorporeal-shock-wave lithotripsy (ESWL) induced renal impairment. The study was performed using 30 rabbits which were divided into two groups. Both groups were exposed to 3,000 shock waves at 18 Kv. The animals in the first group were treated with melatonin for 8 days. Controls and melatonin treated rabbits were killed a week after ESWL. MDA, uric acid and white cell counts were used as markers of oxidative stress. The mean levels of uric acid and white cell counts were significantly lower in the melatonin treated group than in the controls. The mean level of MDA was also significantly lower in the melatonin treated group compared to the controls. Our results show that melatonin may exhibit a protective effect on free radical mediated oxidative damage induced by ESWL in rabbit kidney.
我们的目的是评估内源性强效自由基清除剂褪黑素对体外冲击波碎石术（ESWL）所致肾损伤的影响。该研究使用了30只兔子，将其分为两组。两组均接受18千伏的3000次冲击波。第一组动物用褪黑素治疗8天。ESWL一周后处死对照组和接受褪黑素治疗的兔子。丙二醛（MDA）、尿酸和白细胞计数用作氧化应激的标志物。接受褪黑素治疗组的尿酸和白细胞计数平均水平显著低于对照组。与对照组相比，接受褪黑素治疗组的MDA平均水平也显著降低。我们的结果表明，褪黑素可能对ESWL诱导的兔肾自由基介导的氧化损伤具有保护作用。
