Puledda Francesca, Bruchhage Muriel, O'Daly Owen, Ffytche Dominic, Williams Steven C R, Goadsby Peter J
From the Headache Group, Department of Basic and Clinical Neuroscience (F.P., P.J.G.), Centre for Neuroimaging Sciences, Department of Neuroimaging (M.B., O.O., S.C.R.W.), and Department of Old Age Psychiatry, Institute of Psychiatry, Psychology & Neuroscience (D.F.), King's College London; NIHR-Wellcome Trust King's Clinical Research Facility, SLaM Biomedical Research Centre (F.P., P.J.G.), King's College Hospital, London, UK; and Advanced Baby Imaging Laboratory (M.B.), Warren Alpert School of Medicine at Brown University, Providence, RI.
Neurology. 2020 Sep 29;95(13):e1792-e1799. doi: 10.1212/WNL.0000000000010530. Epub 2020 Aug 5.
To determine whether regional gray and white matter differences characterize the brain of patients with visual snow syndrome, a newly defined neurologic condition, we used a voxel-based morphometry approach.
In order to investigate whole brain morphology directly, we performed an MRI study on patients with visual snow syndrome (n = 24) and on age- and sex-matched healthy volunteers (n = 24). Voxel-based morphometry was used to determine volumetric differences in patients with visual snow. We further analyzed cerebellar anatomy directly using the high-resolution spatially unbiased atlas template of the cerebellum.
Compared to healthy controls, patients with visual snow syndrome had increased gray matter volume in the left primary and secondary visual cortices, the left visual motion area V5, and the left cerebellar crus I/lobule VI area. These anatomical alterations could not be explained by clinical features of the condition.
Patients with visual snow syndrome have subtle, significant neuroanatomical differences in key visual and lateral cerebellar areas, which may in part explain the pathophysiologic basis of the disorder.
为了确定区域灰质和白质差异是否是视觉雪花综合征（一种新定义的神经系统疾病）患者大脑的特征，我们采用了基于体素的形态测量方法。
为了直接研究全脑形态，我们对视觉雪花综合征患者（n = 24）以及年龄和性别匹配的健康志愿者（n = 24）进行了一项磁共振成像（MRI）研究。基于体素的形态测量法用于确定视觉雪花综合征患者的体积差异。我们还使用小脑的高分辨率空间无偏图谱模板直接分析了小脑解剖结构。
与健康对照组相比，视觉雪花综合征患者在左侧初级和次级视觉皮层、左侧视觉运动区V5以及左侧小脑脚I/小叶VI区域的灰质体积增加。这些解剖学改变无法用该疾病的临床特征来解释。
视觉雪花综合征患者在关键视觉和外侧小脑区域存在细微但显著的神经解剖学差异，这可能部分解释了该疾病的病理生理基础。
