From the Department of Rehabilitation and Regenerative Medicine, NewYork-Presbyterian Hospital-University Hospital of Columbia and Cornell, New York, New York.
Weill Cornell Medical College, New York, New York.
A A Pract. 2020 Apr;14(6):e01204. doi: 10.1213/XAA.0000000000001204.
Stiff person syndrome is a neuroimmunological disorder characterized by progressive muscular rigidity and spasms that affect axial/limb muscles, resulting in severe pain and functional limitations. When refractory to conservative treatments, intrathecal baclofen is a viable option to treat the increased tone. Intrathecal baclofen has been shown to accelerate underlying neuromuscular scoliosis in the pediatric population with cerebral palsy. This adverse effect has never been reported in adults with stiff person syndrome. We report a case of an adult with stiff person syndrome and underlying scoliosis who experienced accelerated progression of scoliosis after initiation of intrathecal baclofen, subsequently requiring neurosurgical intervention.
僵人综合征是一种神经免疫性疾病，其特征是进行性肌肉僵硬和痉挛，影响轴/肢体肌肉，导致严重疼痛和功能受限。当保守治疗无效时，鞘内巴氯芬是治疗张力增高的可行选择。鞘内巴氯芬已被证明可加速脑瘫患儿的潜在神经肌肉脊柱侧凸。这种不良反应从未在僵人综合征的成年患者中报告过。我们报告了一例僵人综合征合并脊柱侧凸的成年患者，在开始鞘内巴氯芬治疗后脊柱侧凸进展加速，随后需要神经外科干预。
