Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Nat Rev Immunol. 2020 Dec;20(12):720-726. doi: 10.1038/s41577-020-0397-z. Epub 2020 Aug 5.
Each day, the gastrointestinal tract encounters an influx of microbial and nutrient-derived signals and its physiological activities often adhere to a circadian rhythm. As such, group 3 innate lymphoid cells (ILC3s) that reside in the intestinal mucosa must function within a highly dynamic environment. In this Progress article, we highlight a series of recent reports that have characterized the circadian clock in ILC3s. We discuss how these studies have illustrated the roles of environmental cues and clock genes in regulating ILC3 biology and consider the implications for intestinal immunity.
每天，胃肠道都会接触到大量微生物和营养物质来源的信号，其生理活动通常遵循昼夜节律。因此，存在于肠道黏膜中的固有淋巴细胞 3 型（ILC3）必须在高度动态的环境中发挥功能。在这篇进展文章中，我们重点介绍了一系列最近的报道，这些报道描述了 ILC3 中的生物钟。我们讨论了这些研究如何说明环境线索和时钟基因在调节 ILC3 生物学中的作用，并考虑了它们对肠道免疫的影响。
