Low M G, Saltiel A R
Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons of Columbia University, New York, NY 10032.
Science. 1988 Jan 15;239(4837):268-75. doi: 10.1126/science.3276003.
Glycosylated forms of phosphatidylinositol, which have only recently been described in eukaryotic organisms, are now known to play important roles in biological membrane function. These molecules can serve as the sole means by which particular cell-surface proteins are anchored to the membrane. Lipids with similar structures may also be involved in signal transduction mechanisms for the hormone insulin. The utilization of this novel class of lipid molecules for these two distinct functions suggests new mechanisms for the regulation of proteins in biological membranes.
磷脂酰肌醇的糖基化形式直到最近才在真核生物中被描述，现在已知其在生物膜功能中发挥重要作用。这些分子可以作为特定细胞表面蛋白锚定到膜上的唯一方式。具有相似结构的脂质也可能参与胰岛素激素的信号转导机制。这类新型脂质分子用于这两种不同功能，提示了生物膜中蛋白质调控的新机制。
