Brzezinski-Sinai Noa A, Brzezinski Amnon
Department of Obstetrics and Gynecology, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel.
Departments of Obstetrics & Gynecology, Hadassah-Hebrew-University Medical Center, Jerusalem, Israel.
Front Psychiatry. 2020 Jul 15;11:693. doi: 10.3389/fpsyt.2020.00693. eCollection 2020.
The involvement of gonadal hormones in the pathogenesis of schizophrenia has long been suspected because the psychosis differs in women and men and the illness first makes its appearance shortly after puberty. Changes in sex hormones have been linked with increased vulnerability to mood disorders in women, while testosterone have been associated with increased sexual drive and aggressiveness in men as well as women. Some studies have found abnormal levels of estrogens and testosterone in schizophrenia patients, but the results have been inconsistent and sometimes attributed to the hyperprolactinemia effect of antipsychotics, which may interfere with sex hormones production. The purpose of this review is to present the current knowledge on the link between blood levels of sex-hormones in women during the various stages of the female reproductive life (i.e. puberty, menstrual cycle, pregnancy, contraception, and menopause) and the course of schizophrenia. We also attempt to optimize the clinical approach to women with schizophrenia at these different stages.
长期以来，人们一直怀疑性腺激素参与了精神分裂症的发病机制，因为这种精神病在女性和男性中表现不同，且首次发病多在青春期后不久。性激素的变化与女性情绪障碍易感性增加有关，而睾酮则与男性和女性的性欲增强及攻击性增加有关。一些研究发现精神分裂症患者体内雌激素和睾酮水平异常，但结果并不一致，有时归因于抗精神病药物的高催乳素血症效应，这可能会干扰性激素的产生。本综述的目的是介绍目前关于女性生殖生命各阶段（即青春期、月经周期、怀孕、避孕和更年期）性激素血水平与精神分裂症病程之间联系的知识。我们还试图优化在这些不同阶段对精神分裂症女性患者的临床治疗方法。
