Thomas Megan, Whittle Sarah, Cropley Vanessa
Orygen, Parkville, Victoria, Australia.
Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia.
J Child Psychol Psychiatry. 2025 Aug;66(8):1249-1262. doi: 10.1111/jcpp.14150. Epub 2025 Mar 10.
People with early-life experiences of deprivation are more likely to develop psychotic symptoms. While the mechanisms of this relationship are poorly understood, research suggests a role of cortical development.
In 6323 youth from the Adolescent Brain Cognitive Development study, we examined associations between total, material, interpersonal, cognitive and neighbourhood deprivation at age 9-11 years and psychotic-like experiences (PLEs) 2 years later. We then investigated whether associations were mediated by variation in cortical volume at baseline or rate of change from baseline to follow-up. Sex-specific effects were examined throughout.
All deprivation measures were associated with greater PLEs. Most of these associations were partially mediated by variation in cortical structure in widespread regions, including lower baseline cortical volume in ventral visual and sensorimotor regions and particularly in females, steeper cortical volume decline in association areas.
Early-life deprivation may be associated with psychotic-like experiences via disruption to cortical structure. This phenomenon is common to several forms of deprivation and continues into early adolescence in certain regions.
有早年剥夺经历的人更有可能出现精神病性症状。虽然这种关系的机制尚不清楚，但研究表明皮质发育起了作用。
在青少年大脑认知发展研究中的6323名青少年中，我们研究了9至11岁时的总体、物质、人际、认知和邻里剥夺与两年后的类精神病体验（PLEs）之间的关联。然后，我们调查了这些关联是否由基线时皮质体积的变化或从基线到随访的变化率介导。全程检查了性别特异性效应。
所有剥夺指标都与更多的类精神病体验相关。这些关联中的大多数部分由广泛区域的皮质结构变化介导，包括腹侧视觉和感觉运动区域较低的基线皮质体积，尤其是在女性中，联合区域皮质体积下降更明显。
早年剥夺可能通过破坏皮质结构与类精神病体验相关。这种现象在几种形式的剥夺中都很常见，并在某些区域持续到青春期早期。
