Pontefract Benjamin A, Ho Hong T, Crain Alexandria, Kharel Madan K, Nybo S Eric
Ferris State University, College of Pharmacy, Big Rapids, Michigan, USA.
University of Maryland Eastern Shore, Department of Pharmaceutical Sciences, Princess Anne, Maryland, USA.
Open Forum Infect Dis. 2020 Jul 3;7(7):ofaa276. doi: 10.1093/ofid/ofaa276. eCollection 2020 Jul.
A literature review spanning January 1, 2010, to December 31, 2019, was conducted using the PubMed and ISI Web of Science databases to determine the breadth of publication activity in the area of gram-negative bacteria antimicrobial therapy. The number of articles was used as a reflection of scholarly activity. First, PubMed was searched using the following Medical Subject Headings (MeSH): antibacterial agents, , , and . A total of 12 643 articles were identified within PubMed, and 77 862 articles were identified within ISI Web of Science that included these terms. Second, these articles were categorized by antibiotic class to identify relative contributions to the literature by drug category. Third, these studies were used to identify key trends in the treatment of gram-negative bacterial infections from the past decade. This review highlights advances made in the past 10 years in antibacterial pharmacotherapy and some of the challenges that await the next decade of practice.
我们利用PubMed和ISI科学网数据库进行了一项文献综述，时间跨度为2010年1月1日至2019年12月31日，以确定革兰氏阴性菌抗菌治疗领域的发表活动广度。文章数量被用作学术活动的一个反映。首先，使用以下医学主题词（MeSH）在PubMed中进行检索：抗菌剂、 、 、 和 。在PubMed中总共识别出12643篇文章，在ISI科学网中识别出77862篇包含这些术语的文章。其次，这些文章按抗生素类别进行分类，以确定各药物类别对文献的相对贡献。第三，这些研究被用于识别过去十年中革兰氏阴性菌感染治疗的关键趋势。本综述突出了过去10年在抗菌药物治疗方面取得进步以及未来十年实践中有待应对的一些挑战。 （注：原文中“antibacterial agents”后有缺失内容未给出完整表述）
