Poon M, Cronin D C, Wormser G P, Bottone E J
Department of Microbiology, Mount Sinai Medical Center, New York, NY 10029-6574.
Arch Pathol Lab Med. 1988 Feb;112(2):161-2.
Cryptococcus neoformans strains from 26 individual patients with acquired immunodeficiency syndrome (AIDS) and three isolates from patients without AIDS were tested for their susceptibility to amphotericin B, flucytosine, ketoconazole, and miconazole nitrate. Ninety percent of the C neoformans isolates from patients with AIDS were inhibited by drug concentrations within achievable serum levels. The minimum fungicidal concentration of the four tested antifungal agents, however, exceeded obtainable cerebrospinal fluid levels.
对来自26例获得性免疫缺陷综合征（AIDS）患者的新型隐球菌菌株以及3例非AIDS患者的分离株进行了两性霉素B、氟胞嘧啶、酮康唑和硝酸咪康唑的药敏试验。来自AIDS患者的新型隐球菌分离株中有90%在可达到的血清浓度下受到抑制。然而，四种受试抗真菌药物的最低杀菌浓度超过了可获得的脑脊液浓度。
