Department of Chemistry, University of Zanjan, Zanjan 4537138791, Iran.
Department of Chemistry, University of Zanjan, Zanjan 4537138791, Iran; Research Institute of Modern Biological Techniques (RIMBT), University of Zanjan, Zanjan 4537138791, Iran.
J Control Release. 2020 Nov 10;327:198-224. doi: 10.1016/j.jconrel.2020.08.001. Epub 2020 Aug 5.
Carbon nanotubes (CNTs) have attracted significant attention as promising nanocarriers in the field of drug delivery, due to their properties such as ultrahigh length-to-diameter ratio and excellent cellular uptake. The unique conjugated structure of CNTs suits their surface for π-π stacking interactions with many drugs and therapeutic molecules with aromatic rings, including anthracyclines. Doxorubicin(DOX), as an anthracycline anticancer drug, can be easily adsorbed onto the surface of CNTs via π-π stacking, making the CNTs-DOX conjugation, as the basis of CNT-based drug delivery systems(DDSs) for the delivery of DOX to cancer cells. In this review article, the delivery of DOX using various CNT-based DDSs is presented. In addition, the current progress of in vitro and in vivo research on the design of DOX loaded CNT-based DDSs, including the functionalization and targeting of CNTs, has been reviewed, focusing particularly on emerging technologies and techniques to date for DOX delivery by CNT-based DDSs.
碳纳米管（CNTs）由于其超高的长径比和优异的细胞摄取能力等特性，作为药物传递领域有前途的纳米载体而引起了广泛关注。CNTs 的独特共轭结构适合其表面与许多具有芳环的药物和治疗分子进行π-π 堆积相互作用，包括蒽环类抗生素。阿霉素（DOX）作为一种蒽环类抗癌药物，可通过π-π 堆积轻松吸附在 CNTs 表面，从而使 CNTs-DOX 缀合成为基于 CNT 的药物传递系统（DDS）用于将 DOX 递送至癌细胞的基础。在这篇综述文章中，介绍了使用各种基于 CNT 的 DDS 来传递 DOX。此外，还回顾了目前关于设计基于 DOX 负载 CNT 的 DDS 的体外和体内研究的最新进展，包括 CNT 的功能化和靶向，特别关注迄今为止用于 CNT 基 DDS 传递 DOX 的新兴技术和技术。
