Physics Department, Belarusian State University, 4 Nezavisimosti Ave., Minsk 220030, Belarus.
Curr Pharm Des. 2018;24(43):5207-5218. doi: 10.2174/1381612825666190117095132.
In spite of considerable efforts of researchers the cancer deseases remain to be incurable and a percentage of cancer deseases in the structure of mortality increases every year. At that, high systemic toxicity of antitumor drugs hampers their effective use. Because of this fact, the development of nanosystems for targeted delivery of antitumor drugs is one of the leading problem in nanomedicine and nanopharmacy.
To critically examine the modern strategies for carbon nanotubes (CNTs)-based delivery of anticancer quinones and to summarize the mechanisms which can provide high effectiveness and multifunctionality of the CNT-based quinone delivery platform.
Quinones, including anthracycline antibiotics - doxorubicin and daunorubicin, are among the most prospective group of natural and syntetic compounds which exhibit high antitumor activity against different type of tumors. In this review, we focus on the possibilities of using CNTs for targeted delivery of antitumor compounds with quinoid moiety which is ordinarily characterized by high specific interaction with DNA molecules. Quinones can be non-covalently adsorbed on CNT surface due to their aromatic structure and π-conjugated system of double bonds. The characteristic features of doxorubicine-CNT complex are high loading efficiency, pH-dependent release in acidic tumor microenviroment, enough stability in biological fluid. Different types of CNT functionalization, targeting strategies and designs for multifunctional CNT-based doxorubicine delivery platform are disscussed.
Nanosystems based on functionalized CNTs are very promising platform for quinone delivery resulting in significant enhancement of cancer treatment efficiency. Functionalization of CNTs with the polymeric shell, especially DNA-based shells, can provide the greatest affinity and mimicry with biological structures.
尽管研究人员付出了相当大的努力，但癌症仍然无法治愈，癌症在死亡率中的比例每年都在增加。此外，抗肿瘤药物的全身毒性很高，这阻碍了它们的有效使用。出于这个原因，开发用于靶向输送抗肿瘤药物的纳米系统是纳米医学和纳米药学的主要问题之一。
批判性地研究基于碳纳米管（CNT）的抗癌醌类药物输送的现代策略，并总结能够提供基于 CNT 的醌类药物输送平台高效性和多功能性的机制。
醌类化合物，包括蒽环类抗生素-多柔比星和柔红霉素，是最有前途的天然和合成化合物之一，对不同类型的肿瘤具有高抗肿瘤活性。在这篇综述中，我们专注于使用 CNT 靶向输送具有醌部分的抗肿瘤化合物的可能性，醌部分通常以与 DNA 分子的高特异性相互作用为特征。由于其芳香结构和双键的π共轭系统，醌类可以非共价吸附在 CNT 表面上。多柔比星-CNT 复合物的特征是在酸性肿瘤微环境中具有 pH 依赖性释放、在生物流体中足够的稳定性和高载药量。讨论了不同类型的 CNT 功能化、靶向策略和多功能基于 CNT 的多柔比星输送平台的设计。
基于功能化 CNT 的纳米系统是醌类药物输送非常有前途的平台，可显著提高癌症治疗效率。用聚合物壳，特别是基于 DNA 的壳对 CNT 进行功能化，可以提供与生物结构最大的亲和力和模拟性。
