Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8560, Japan.
Department of Ophthalmology, Akita University Graduate School of Medicine, 1-1-1 Hondou, Akita, 010-0041, Japan.
Sci Rep. 2020 Aug 6;10(1):13227. doi: 10.1038/s41598-020-70197-6.
The purpose of this cross-sectional retrospective study was to determine the relationship between the retinal displacements and the retinal thickness in eyes with epiretinal membrane (ERM) after vitrectomy with internal limiting membrane (ILM) peeling. To accomplish this, we measured the retinal thickness using optical coherence tomography (OCT) and the retinal displacement using OCT angiography to obtain 3 mm × 3 mm en face images before, and 2, 4, and 8 weeks following the surgery from 20 eyes of 20 patients. The distance between the retinal vessel bifurcations and the fovea was significantly displaced centrifugally and asymmetrically in the 4 quadrants postoperatively (P < 0.001). The foveal avascular zone (FAZ) was significantly enlarged, and the central foveal thickness (CFT) and the inner nuclear layer (INL) thickness were significantly thinner postoperatively. The displacements were significantly correlated with the changes in the FAZ area (r = 0.717, P < 0.001), the CFT (r = - 0.702, P < 0.001), and the INL thickness (r = - 0.702, P < 0.001). In conclusion, the distance between the retinal bifurcations and the fovea was asymmetrically expanded after the surgery and was significantly correlated with the morphological changes. These results indicate that a horizontal macular contraction is correlated with vertical retinal contraction in the eyes with an ERM.
本横断面回顾性研究的目的是确定内界膜（ILM）剥除玻璃体切除术后外膜（ERM）眼视网膜移位与视网膜厚度之间的关系。为此，我们使用光学相干断层扫描（OCT）测量视网膜厚度，使用 OCT 血管造影术获得视网膜位移，以获得 20 例 20 只眼术前、术后 2、4 和 8 周的 3mm×3mm 面状图像。术后 4 个象限中视网膜血管分支与黄斑中心凹之间的距离呈离心性和不对称性显著移位（P<0.001）。黄斑无血管区（FAZ）显著增大，中央黄斑厚度（CFT）和内核层（INL）厚度显著变薄。这些移位与 FAZ 面积的变化显著相关（r=0.717，P<0.001）、CFT（r=-0.702，P<0.001）和 INL 厚度（r=-0.702，P<0.001）。总之，手术后视网膜分支与黄斑中心凹之间的距离呈不对称性扩大，与形态学变化显著相关。这些结果表明，ERM 眼中水平黄斑收缩与垂直视网膜收缩相关。
