Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Japan.
Invest Ophthalmol Vis Sci. 2013 Jan 21;54(1):629-35. doi: 10.1167/iovs.12-10907.
To investigate the papillofoveal distance and its association with retinal thickness on optical coherence tomography (OCT) images after vitrectomy for diabetic macular edema (DME).
In this retrospective case series, 72 eyes of 57 consecutive patients who underwent vitrectomy for DME were included. Retinal images dissecting the fovea horizontally were obtained using OCT before and after vitrectomy. After identification of the disc margin and the presumed foveal center, the papillofoveal distance was measured on the OCT images. The association of the distance with retinal thickness and peeling of the inner limiting membrane (ILM) was evaluated.
The papillofoveal distance was significantly shorter after vitrectomy (3956.1 ± 299.0 μm vs. 3759.6 ± 331.3 μm; P < 0.001), and the shortening was correlated negatively with the total and inner retinal thickness in the temporal subfield (r = -0.29, P = 0.012 and r = -0.34, P = 0.004, respectively). Shortening of the papillofoveal distance was greater in 54 eyes in which ILM peeling was performed compared with 18 eyes in which ILM peeling was not performed (234.7 ± 159.3 μm vs. -9.7 ± 83.5 μm; P < 0.001). No differences were seen in the papillofoveal distance and retinal thickness before and after surgery between eyes with and without preoperative epiretinal membrane or posterior vitreous detachment. The total and inner thicknesses in the temporal subfield were thinner postoperatively in eyes that underwent ILM peeling than those without ILM peeling (P < 0.001 and P < 0.001).
The papillofoveal distance on OCT images was shortened and the retina in the temporal subfield was thinner in eyes that underwent ILM peeling to treat DME.
研究糖尿病性黄斑水肿（DME）玻璃体切除术后光学相干断层扫描（OCT）图像上的视乳头-中心凹距离及其与视网膜厚度的关系。
本回顾性病例系列研究纳入了 57 例连续接受 DME 玻璃体切除术的 72 只眼。玻璃体切除术前和术后，使用 OCT 获得水平分割黄斑的视网膜图像。在确定视盘边缘和假定的中心凹后，在 OCT 图像上测量视乳头-中心凹距离。评估距离与视网膜厚度和内界膜（ILM）剥除的相关性。
玻璃体切除术后视乳头-中心凹距离明显缩短（3956.1 ± 299.0 μm 比 3759.6 ± 331.3 μm；P < 0.001），缩短与颞侧亚区总视网膜和内视网膜厚度呈负相关（r = -0.29，P = 0.012 和 r = -0.34，P = 0.004）。与未行 ILM 剥除的 18 只眼相比，行 ILM 剥除的 54 只眼中视乳头-中心凹距离缩短更大（234.7 ± 159.3 μm 比 -9.7 ± 83.5 μm；P < 0.001）。术前有或无视网膜前膜或后玻璃体脱离的眼，手术前后视乳头-中心凹距离和视网膜厚度无差异。与未行 ILM 剥除的眼相比，行 ILM 剥除的眼颞侧亚区总视网膜和内视网膜厚度术后更薄（P < 0.001 和 P < 0.001）。
行 ILM 剥除治疗 DME 的眼 OCT 图像上视乳头-中心凹距离缩短，颞侧亚区视网膜变薄。
