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本文引用的文献

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2
Dynamics of Neutrophils-to-Lymphocyte Ratio Predict Outcomes of PD-1/PD-L1 Blockade.中性粒细胞与淋巴细胞比值的动态变化可预测 PD-1/PD-L1 阻断治疗的结局。
Biomed Res Int. 2017;2017:1506824. doi: 10.1155/2017/1506824. Epub 2017 Nov 28.
3
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity.肿瘤相关巨噬细胞的PD-1表达抑制吞噬作用和肿瘤免疫。
Nature. 2017 May 25;545(7655):495-499. doi: 10.1038/nature22396. Epub 2017 May 17.
4
Difference in Leukocyte Composition between Women before and after Menopausal Age, and Distinct Sexual Dimorphism.绝经前后女性白细胞组成的差异以及明显的性别二态性。
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Prognostic significance of the neutrophil to lymphocyte ratio in patients with non-small cell lung cancer: a systemic review and meta-analysis.非小细胞肺癌患者中性粒细胞与淋巴细胞比值的预后意义：一项系统评价和荟萃分析
Int J Clin Exp Med. 2015 Mar 15;8(3):3098-106. eCollection 2015.
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Utility of pre-treatment neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as prognostic factors in breast cancer.治疗前中性粒细胞与淋巴细胞比值及血小板与淋巴细胞比值作为乳腺癌预后因素的效用
Br J Cancer. 2015 Jun 30;113(1):150-8. doi: 10.1038/bjc.2015.183. Epub 2015 May 28.
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Cholesterol: A modulator of the phagocyte NADPH oxidase activity - A cell-free study.胆固醇：吞噬细胞NADPH氧化酶活性的调节剂——一项无细胞研究。
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Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors.47个新发现的乳腺癌易感基因座与环境危险因素之间的基因-环境相互作用研究。
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Cancer Epidemiol Biomarkers Prev. 2014 Jun;23(6):934-45. doi: 10.1158/1055-9965.EPI-13-0901. Epub 2014 Mar 17.
10
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中性粒细胞与淋巴细胞比值与乳腺癌风险：基于亚型的分析及潜在的交互作用。

Neutrophil to lymphocyte ratio and breast cancer risk: analysis by subtype and potential interactions.

机构信息

Galician Public Foundation of Genomic Medicine (FPGMX), Genomic Medicine Group, International Cancer Genetics and Epidemiology Group, Health Research Institute of Santiago (IDIS), Santiago de Compostela, Spain.

Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.

出版信息

Sci Rep. 2020 Aug 6;10(1):13203. doi: 10.1038/s41598-020-70077-z.

DOI:10.1038/s41598-020-70077-z
PMID:32764699
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7413522/
Abstract

Multiple studies have found the neutrophil to lymphocyte ratio (NLR) to be associated with adverse breast cancer (BC) prognosis and survival. Very limited data exist on the role of NLR and risk of BC. The BREOGAN study is a population-based case-control study conducted in Galicia, Spain. We examined the WBC- and NLR-BC relationships. The risk of BC increased with increasing levels of neutrophils percentage (NE%) (multivariable OR for the highest category (95% CI) = 2.14 (1.39-3.32), P-trend < 0.001) and of the NLR (multivariable OR for the highest category (95% CI) = 1.93 (1.26-2.97), P-trend < 0.001). Lymphocytes absolute (L#) and percentage (L%) were associated with a decreased risk of BC (multivariable OR for the highest category (95% CI) = 0.54 (0.35-0.83), and 0.51 (0.33-0.79), P-trend = 0.001 and < 0.001, respectively). The NLR-BC association was more pronounced among Luminal A BC (multivariable OR for the highest category (95% CI) = 2.00 (1.17-3.45), P-trend < 0.001), HER2-negative BC (multivariable OR for the highest category (95% CI) = 1.87 (1.16-3.02), P-trend < 0.001), and those with high total cholesterol and low HO levels.

摘要

多项研究发现中性粒细胞与淋巴细胞比值（NLR）与不良乳腺癌（BC）预后和生存相关。关于 NLR 和 BC 风险的作用，仅有非常有限的数据。BREOGAN 研究是在西班牙加利西亚进行的一项基于人群的病例对照研究。我们研究了白细胞计数（WBC）和 NLR 与 BC 的关系。BC 的风险随着中性粒细胞百分比（NE%）水平的升高而增加（最高类别（95%CI）的多变量 OR = 2.14（1.39-3.32），P 趋势 < 0.001）和 NLR（最高类别（95%CI）的多变量 OR = 1.93（1.26-2.97），P 趋势 < 0.001）。淋巴细胞绝对值（L#）和百分比（L%）与 BC 风险降低相关（最高类别（95%CI）的多变量 OR = 0.54（0.35-0.83）和 0.51（0.33-0.79），P 趋势 = 0.001 和 < 0.001）。NLR 与 BC 的相关性在 Luminal A BC 中更为明显（最高类别（95%CI）的多变量 OR = 2.00（1.17-3.45），P 趋势 < 0.001），HER2 阴性 BC（最高类别（95%CI）的多变量 OR = 1.87（1.16-3.02），P 趋势 < 0.001）和总胆固醇高和 HO 水平低的患者中更为明显。