Mayer V W, Goin C J, Taylor-Mayer R E
Genetic Toxicology Branch, Food and Drug Administration, Washington, DC 20204.
Environ Mol Mutagen. 1988;11(1):31-40. doi: 10.1002/em.2850110105.
A number of solvent compounds that were tested in Saccharomyces cerevisiae were potent inducers of aneuploidy, although they did not induce any other genetic effects. As an extention of these earlier findings, 1-methyl-2-pyrrolidinone was tested and was found to induce aneuploidy. Several structurally related compounds were also tested; 2-pyrrolidinone induced aneuploidy, but succinimide, pyrrolidine, 1-methylpyrrolidine, 1-methyl-3-pyrrolidinol, and 2-pyrrolidineethanol did not. Maleimide and its N-hydroxy, N-methyl, and N-ethyl derivatives were also negative for aneuploidy induction.
在酿酒酵母中测试的许多溶剂化合物是有效的非整倍体诱导剂，尽管它们不会诱导任何其他遗传效应。作为这些早期发现的延伸，对1-甲基-2-吡咯烷酮进行了测试，发现它能诱导非整倍体。还测试了几种结构相关的化合物；2-吡咯烷酮能诱导非整倍体，但琥珀酰亚胺、吡咯烷、1-甲基吡咯烷、1-甲基-3-吡咯烷醇和2-吡咯烷乙醇则不能。马来酰亚胺及其N-羟基、N-甲基和N-乙基衍生物在诱导非整倍体方面也呈阴性。
